Optical microscopes are widely used in biomedical research and clinical medicine. In recent years, deep learning technology has provided advanced algorithm support for the automatic analysis of microscopic images. However, most of the microscopes currently installed in Chinese hospitals and scientific research institutions do not have their own deep neural network image analysis function, and the upgrade of equipment and software requires high costs. This research used portable computing devices to upgrade traditional digital optical microscopes with artificial intelligence, and used Jetson TX2 portable devices to run Faster R-CNN network to achieve three-frame rate classification and detection efficiency for zebrafish eggs. The detection sensitivity was higher than 0.88, the specificity is higher than 0.94, and the portable device used was small and could be conveniently placed next to the microscope. This research provides a convenient, inexpensive and popular technical solution for artificial intelligence to empower traditional microscopes.

Objective To develop a set of temperature and speed control device for blood transfusion and infusion suitable for onsite emergency medical rescue, which can realize fast and accurate liquid infusion and heating, and has automatic exhaust function. Methods Pro/E modeling software was used to design the three-dimensional structure. The microprocessor chip PIC16F1947 was used as the core of the host while a new type of peristaltic pump was selected to realize the precision of flow-rate control. The detachable heater was used alone to communicate with the host by PIC16F1936 microprocessor, and realized temperature control by PID algorithm.The aluminum alloy material was used as the heat transfer surface of the heating box, and improved the heating efficiency by the design of double-sided heating and the opposed toothed aluminum plate. Results The speed-control device for emergency blood transfusion and infusion and temperature control with a maximum speed of 200 mL/min was developed, which can meet the clinical requirements of heating and pressurizing rapid blood transfusion and infusion. The machine had advanced design and convenient operation, and suitable for heating of short-time large-volume blood transfusion and infusion. Conclusion The device could meet the requirements of infusion treatment for various seriously injured persons, and plays an important role in emergency medical rescue on site and outside of the hospital.

Objective To detect performance of cardiac defibrillator in hospital and to reveal the risk of present situation, so as to put forward risk control suggestions. Methods According to National Metrological technical specification (JJF1149-2014 Calibration Specification for Cardiac Defibrillators), testing instrument was applied to obtain data and then statistical method was using to analyze the influence of hospital level, years of use, domestic or import, maintenance cycle, training record on the failure of defibrillator. Results One or more unqualified items were found in 14 sets, and the use years affected the appearance or normal function, and the source of manufacturer, hospital maintenance and personnel training affected the charging time or energy release. During the storage period, the energy decreased with time. Conclusion Regular inspection and maintenance are important, and strengthening the management of energy-released equipment and determining the appropriate economic service life can improve the quality and safety level of defibrillator, and also ensure the effectiveness and economy of clinical use.

Objective To train and evaluate a U-Net-based automatic segmentation technique for delineating organs at risks (OARs) of breast cancer. Methods A total of 140 cases of breast tumors were selected in the experiment, 120 of which were used as training sets to build U-Net-based automatic segmentation model, and the remaining 20 cases were used as test sets to test the accuracy of the automatic contouring methods. Dice similarity coefficient (DSC) and mean distance to agreement (MDA) were used to evaluate the contouring results of the trained auto-segmentation model, and compared with the atlas-based auto-segmentation method with the same training and test sets. Results The mean DSC values of OARs sketched by U-Net-based automatic contouring models were higher than atlas-based automatic contouring methods; and the mean MDA values of OARs sketched by U-Net-based automatic contouring models were lower than the latter. The differences in DSC values of the two auto-segmentation methods in bilateral lungs, normal breasts, and heart, as well as the differences in MDA values in left lung, normal breasts, and heart were statistically significant (P<0.05). Conclusion U-Net-based automatic segmentation model has a better contouring effect in OARs of breast cancer, and its contouring accuracy is higher than that of atlas-based auto segmentation method.

Objective To evaluate the advantages of low dose vascular system in transcatheter atrial septal defect (ASD) surgery, and to explore the factors and methods of dose reduction of intraoperative radiation and radiation. Methods From July 2018 to December 2019, 339 patients received transcatheter treatment of ASD were divided into two group: FD10 clarity system and FD10 system. The difference between the two groups was statistically analyzed by collecting the data of dose area product (DAP) and air kerma (AK). Results The average DAP value of FD10 clarity system was 5702 mGy.cm2 which was lower than 8576 mGy.cm2 of FD10 system, decreased by 33.51%; the average AK value of FD10 clarity system was 34.41 mGy, lower than 74.94 mGy of FD10 system, decreased by 54.08%. Conclusion Compared with the traditional vascular system, the low dose vascular system has an obvious advantage of radiation dose in the transcatheter treatment of ASD heart disease.

Objective To explore the variation rules of physical parameters during the operation of Prisma 3.0T magnetic resonance, and to provide the data reference for precision quality control. Methods Aquiferre system was used to realize real-time monitoring and collection of operational data by connecting the cloud server with Prisma magnetic resonance. Results The physical parameters such as liquid helium level, liquid helium pressure, cold head temperature, shielding layer temperature and pressure balance heating power were obtained and the real-time data of scanning quantity and imaging methods were counted. Conclusion The simultaneous occurrence of abnormal conditions such as increased liquid helium pressure and cold head temperature, and reduced pressure balance heating power may result from the abnormal decrease in pressure balance heating power, and this abnormality leads to the loss of 0.2% liquid helium. The monthly workload of Prisma collected and the imaging methods applied are counted, and the curve of the scan volume with time and the monthly proportion of imaging methods are obtained, which provides reliable data support for the realization of equipment economic benefit analysis and the development of new functions.

electric drill cleaning brush; cavity apparatus; cleaning efficiency; cleaning quality

Miniature axial flow pumps are widely used in medical auxiliary blood supply, but most of them are models of constant flow blood supply, and there is no research on axial flow pumps providing pulsatile assistance. In this paper, the feasibility of the axial blood pump in providing pulsatile blood flow was studied by establishing experimental models, controlling the feedback system, and monitoring the system pressure and flow in real time by pressure sensors and flow sensors. The results showed that the axial flow pump can better achieve the perfusion effect of pulsatile blood flow, the pressure curve is close to the natural pulsation curve, the flow rate meets the perfusion demand, and verified preliminarily the hemolytic performance of the blood pump of this method.

Objective To design a portable ultrathin electronic bronchoscope with a diameter of 1.2~3.6 mm for the examination and treatment of grade 8-11 bronchus. Methods The portable ultrathin electronic bronchoscope was consisted of a body, a display host and a large screen component. The body included freely bendable insertion part, camera part, lighting part, etc. The display host included image processing and control parts, display parts, interface modules, etc. The camera part used miniature low-power image sensor and ultrathin special shielding wire. The lighting part used miniature high-brightness LED to generate light, and provided illumination for the camera part through optical fibers. Combined with advanced image processing and control technology, it can perform medical operation better. Results A non-working channel endoscope with an outer diameter of 1.2 mm and a resolution of up to 40000 pixels was successfully designed by 0.6 mm edge-length miniature image sensor, And endoscope with an outer diameter of 2.8 mm and a resolution of up to 160000 pixels was successfully designed by 1.1 mm edge-length miniature image sensor and 1.2 mm working channel. Conclusion The ultrathin electronic bronchoscope achieved the effect of ultrathin and no heat, and adopted advanced technologies such as portable, storage, wireless and so on, which is more convenient for users to use and teach, and observation for tracheal intubation.

Objective To propose a rough neural network model based on data mining technology, which provides a reference method for medical equipment fault monitoring and identification. Methods Ventilator failure alarm events were collected from October 2017 to May 2019 in our hospital as research objects, and developed a method for collecting fault factors, including environmental factors, electrical factors, and pneumatic factors from the equipment. Meanwhile, we built a rough neural network model with eight inputs and three outputs. We used the training set and the test set to train and test the rough neural network model, respectively. Results After training set learning, the sensitivity, specificity and accuracy of the training set ventilator failure mode were 87.8%, 85.6% and 91.1%, respectively. The accuracy of the test set ventilator failure mode was 85.0%. Conclusion By mining the potential relationship between fault modes and fault factors, the fault modes can be well identified. The rough neural network model can provide a reference method for the monitoring and identification of medical equipment faults.

With the application of wearable and IoT technologies in the fields of medical and healthcare, a large amount of continuous dynamic physiological data has been generated. At present, there is a lack of effective methods and models in the collection, storage and communication of continuous dynamic physiological data all over the world. In this paper, the collection storage and exchange utilization of continuous dynamic physiological data were explored from two aspects of real-time and off-line. For the continuous physiological signals transmitted in real time, the data acquisition and storage problems were solved based on the time series database InfluxDB. For offline data secondary analysis and utilization, the problem of multi-source heterogeneous data integration and secondary exchange and utilization was solved by using HDF5 file format. This technical solution is used in the accompanying physical monitoring of the clinical department of our hospital, which effectively solves the problem of continuous dynamic physiological data collection-storage and communication utilization. Moreover, this study provides an effective solution for the collection, storage, and exchange of this data.

Objective To study the changes of blood flow signals and spectral characteristics of the electrical impedance of human lower limbs before and after high-intensity exercise, and to lay the foundation for evaluating the motor function and fatigue degree of human body using electrical impedance parameters. Methods Using the electrical impedance rapid measurement system developed by the research group, the impedance blood flow signals of the lower limbs of 10 volunteers before and after high-intensity exercise and the amplitude of the electrical impedance of 1 kHz to 1 MHz band were measured. Results The impedance blood flow signal characteristics showed that the amplitude of the impedance blood flow signal of the lower limbs of the human body increased by 22%±13% after exercise. The analysis of the impedance spectrum showed that the influence of motion on impedance amplitude of lower limb was not significant in frequency band below 100 kHz. In the above frequency band above 100 kHz, the amplitude of electrical impedance of lower limbs after exercise decreased significantly after exercise. The higher the measurement frequency, the more obvious the degree of decline. The rate of change at 1 MHz could reach 53%±14%. Conclusion The electrical impedance of human body has a close relationship with the state of motor function. Therefore, the electrical impedance parameter is expected to be an important indicator for qualitatively and quantitatively distinguishing tissue fatigue state.

A new type fixture and calculation program were used to test the four-point bending of metal bone plates, and different test methods in YY/T 0342-2002 were compared and analyzed on this basis. The deflection values of samples at different positions could be obtained by the fixture and analysis software, and equivalent bending stiffness was obtained by different formulas in YY/T 0342-2002, effectively avoiding the errors existing in different samples and two test operations. According to the theoretical research and data analysis of this paper, accurate, scientific and objective test data can be obtained for the supervision, random checking and product development of metal bone plates.

Objective To explore the feasibility of magnetic anchoring device in assisting trocar-less laparoscopic hysterectomy. Methods Four healthy female Beagle dogs were used as models, and the magnetic anchoring device designed and developed by ourselves was used to complete the canine hysterectomy by two-ports method. The operation time, blood loss, and the operation convenience evaluated by the surgeon were recorded. Results Four Beagle dogs successfully completed the twoports laparoscopic hysterectomy with the aid of magnetic anchoring device. The operation time was 27-51 min, the blood loss was less than 20 mL. During the operation, the use of titanium alloy tissue forceps could successfully achieve the clamping and release of the internal grasping forceps. The internal grasping forceps had no complications, such as slippage and tissue damage after clamping the tissue. The internal grasping forceps could fully reveal the surgical field under the pull anchor of the external anchoring magnet. Conclusion Magnetic anchoring device can provide good surgical field exposure and tissue pulling for the trocar-less laparoscopic hysterectomy, which has great clinical application value.

This study aims to develop a new intelligent extended medical shelter suitable for medical rescue and physical examination, and to establish a mobile platform for fast and efficient inspection. The medical shelter adopted second class chassis of commercial vehicle with reasonable layout and large expansion, which could meet the requirements of X-ray, ultrasound, ECG, biochemical and humoral examination. The new mobile intelligent expansion inspection and inspection medical shelter has the characteristics of complete functions, reasonable layout, strong adaptability and strong maneuverability, which can meet the needs of medical examination and rescue, and has a broad application prospect.

Objective To understand the resource allocation and development of respiratory endoscopy in 102 public hospitals in Anhui province, so as to provide a basis for the quality management, popularization and development of respiratory endoscopy. Methods By the questionnaire on the current application of respiratory endoscopy in Anhui Province, the survey was conducted in 102 public hospitals in Anhui province to collect data for analysis. Results Of the 34 3A grade hospitals, 32 had specialized respiratory endoscopy facilities. Of 68 non-3A grade hospitals, 66 had respiratory endoscopy facilities. There were 125 electronic bronchoscope hosts in 102 hospitals, with a total of 178 mirrors, but only 12 hospitals has separate decontamination rooms for respiratory endoscopes. There were 60 hospitals with more than 3 doctors who can operate respiratory endoscopys. All 34 3A grade hospitals had applied respiratory endoscopy more than 5 years, and only 39 of non-3A grade hospitals had the duration of respiratory endoscopy treatment more than 5 years. Endoscopic foreign body removal and endoscopic drug injection were the most common endoscopic treatment. Of 102 hospitals, only 41 hospitals regularly participated in the training, and only 31 hospitals could conduct the diagnosis and treatment of tuberculosis. Conclusion It is necessary to strengthen the allocation of respiratory endoscopy facilities and the training of professional technicians of respiratory endoscopy, improve and standardize the overall operation technology of respiratory endoscopy, and promote the healthy development of related diagnosis and treatment.

Objective To evaluate the biocompatibility of a novel uterine tamponade balloon catheter, which provides a basis for its safe application in clinical practice. Methods The biological properties of the uterine tamponade balloon catheters were investigated by in vitro cytotoxicity test, skin sensitization test, intradermal reaction test, vaginal irritation test, hemolysis test and pyrogen test. Results The cell survival rate was 86%, suggesting no potential cytotoxicity. The balloon catheter had no skin sensitization, intradermal reactions, and vaginal irritation response. The hemolysis rate of the balloon catheter was 0.3%. The sum of body temperature rise of rabbits was 0.1℃, suggesting no pyrogen reaction. Conclusion The novel uterine tamponade balloon catheter complies with the relevant national standards and has good biocompatibility, which provides a reliable guarantee for its clinical application.

In this paper, the dynamic and steady performances of infant incubator were intuitively analyzed based on automatic control theory by establishing the mathematical model of the temperature control system of the incubator. Based on the theoretical model and the measured data of temperature control of the incubator in our hospital, the temperature control performance of infant incubator in use was evaluated and analyzed. The factors related to the temperature runaway of infant incubator for infants were summarized, and the precautionary maintenance and the matters needing attention and improving methods in use were put forward.

Nitinol materials with routine modeling procedure was subjected to comprehensive biosecurity evaluation to provide safe basis for the production and application of medical products, especially in the area of implant interventional devices. To simulate the routine application of nitinol in the production of medical devices, nitinol material was molded into nitinol wire. Then, based on a series of GB/T 16886 medical equipment biology evaluation standards, nitinol wire was subjected to a series of tests, including pyrogen test, cytotoxicity test, intradermal reaction test, late-onset hypersensitivity test, hemolysis test, thrombosis test, sub-chronic systemic toxicity test, muscular implantation test, acute systemic toxicity test, and genotoxicity test. The result showed that the biological safety of nitinol materials after thermal oxidation treatment under common atmosphere conforms to the requirements of current standards.

Objective To understand the structure, length and volume of different extracorporeal circulation pipelines for hemodialysis, and compare the differences in structure, length and volume of different pipelines. Methods Two kinds of general pipelines (A and B) and one special pipeline C were selected as the research objects. The structure of each pipeline and the fixing position of extracorporeal circulation components in a certain model of dialyzer were described. The length and volume of each extracorporeal circulation pipeline were measured by tape measure and syringe, respectively. The difference of length and volume between general pipelines and special pipeline was compared. Results The structure of the general pipelines was similar to that of the special pipeline, but the inner diameter of the artery-pump segment of the special pipeline was smaller than that of the general pipeline. The length of the pump pipes-arterial pot section of two general pipelines was too long, which was 4.8 times and 5.2 times of the special pipeline, respectively. The volume of arterial section of two general pipelines was about 30 mL more than that of the special pipeline. Conclusion The general extracorporeal circulation pipelines for hemodialysis should be adapted to dialyzers in order to reduce the blood volume of extracorporeal circulation and the contact area between blood and pipelines.

Objective To design a warning system for Siemens accelerator multi-leaf Collimator (MLC) motor life to realize the early warning when the motor life reaches the warning value. Methods VC++ program was used to read the plan file exported in the plan system and the log file in the network transmission system, respectively. The daily travel of 82-leave collimators was calculated and accumulated from the date of replacement. The average life of 10 motors was calculated as the average life, and the ratio of accumulative travel to average life was life progress. The life schedule was updated at 24 PM every night. Results The real-time update of MLC motor life schedule of Siemens accelerator was realized every day by the warning system. If the life progress was more than 90%, the warning system would give an alarm. Conclusion The use of early warning system reduces the workload of equipment maintenance engineers, improves the opening rate of machines, and increases the therapeutic effect of patients.

Objective To design a data acquisition system to digitize the experimental data of the old medical multi-channel physiological recorder. Methods ADC12 module and FLASH memory chip in MSP430F149 microcontroller were selected to develop the data acquisition system of medical multi-channel physiological recorder. In the design of hardware circuit, the peripheral interface circuit of MSP430F149 microcontroller and the RS232 communication circuit between microcontroller and microcomputer system were mainly introduced. In the development of software, the timing A/D conversion program of MSP430F149 microcontroller and the RS232 communication program between microcontroller and microcomputer system were developed by C language. Results The analog experimental data of the old medical multi-channel physiological recorder were digitized by A/D conversion program, and stored in the microcomputer through communication. The acquisition system could realize multi-channel data acquisition, with high accuracy. Conclusion The data acquisition system has the characteristics of low cost, simple structure and high reliability, and can widely used in the hardware system of biosignal detection, recording and analysis in the functional experiments.

Objective To develop a new type of limb warm sheath, which can be applied to the limb thermal insulation of patients undergoing femur closed reduction. Methods The limb warm sheath was equipped with heat preservation layer, heating layer and heat insulation layer from the inside to the outside. The heat preservation layer was equipped with a temperature sensing device and the outer surface of the sheath had a temperature indicator and a temperature regulator. By comparing with the conventional insulation measures, the effect of the new body insulation sheath was discussed. Results In the operation of closed reduction of femur, the thermal insulation effect of the new limb thermal insulation sheath was better than that of the conventional thermal insulation measures in the operation and postoperative patients (P<0.05). Patients with the new limb thermal insulation sheath had high comfort in temperature, short postoperative recovery time, and low incidence of hypothermia and chills, with statistically significant differences compared with the control group (P<0.05). Conclusion The new limb thermal sheath can effectively reduce the occurrence of hypothermia in patients undergoing closed reduction of femur surgery, and it also has the function of monitoring and regulating the temperature, which is worthy of clinical application.

To design a disposable special lock for medical rescue vehicle to solve the complicated problem of unlocking the old hospital rescue vehicle. Using the disposable special lock in the medical rescue vehicle can centrally manage a number of drawers and cabinets, and can open the drawers and cabinets easily. After the use of disposable plastic lock, the time used by nurses to pick up drugs, items and check items was significantly lower than before the use, and the completion rate of first-aid drugs and items in the rescue vehicle was significantly higher than before the use. The design of disposable special lock is simple, safe and practical, and its transformation cost is low, which can reduce the workload of nurse handover, and has a good application prospect and practical significance.

Objective To evaluate the feasibility and accuracy of DeepViewer software in the automatic delineation of heart structure for patients with breast cancer after breast-conserving surgery. Methods Twenty patients with breast cancer after breast-conserving surgery were enrolled in this study, including 10 patients with left breast cancer and 10 with right breast caner. In order to evaluate the feasibility and accuracy of DeepViewer for automatic delineation of heart structure, differences in volume and position, dice similarity coefficient (DSC), and delineation time were assessed between the automatic delineation and manual delineation. Meanwhile, the data of left and right breast cancer were compared. Results The volume difference (ΔV%), total position difference (ΔL) and DSC between the automatic delineation and manual delineation were -21.43%±5.52%, (0.37±0.19) cm, 0.84±0.03, respectively. Automatic delineation saved about 84% of delineation time compared to manual delineation. The DSC values were 0.83±0.03 and 0.85±0.02 for patients with left and right breast cancer, respectively, with no statistical difference between the two groups (P>0.05). Conclusion Using DeepViewer software in automatic of heart structure for patients after breast cancer conserving surgery can achieve satisfactory results, shorten the delineation time, and improve the work efficiency of radiotherapy.

The retina is a biological tissue with high oxygen metabolism. When there is an ocular lesion or systemic disease of the human body, there are abnormal retinal blood oxygen metabolism and regulating disorders correspondingly. The measurement of retinal oxygen saturation level is of clinical significance. Currently, scientific-grade detectors are generally employed in both commercially developed instruments and laboratory prototypes that allow for the non-invasive detection of retinal oxygen saturation. However, these scientific-grade detectors are very expensive and to some extent it hinders the mass production and sales of the retinal oxygen saturation measurement instruments. In this study, a non-invasive retinal blood oxygen saturation measurement system was designed based on a fundus camera with the single-lens reflex (SLR) camera as the detector. Specifically, the Nikon D70 SLR camera was used as the detector in the system for its ideal spectral response curves of the green and red channels. By extracting the corresponding retinal imaging information on the green and red channels, the functional blood oxygen saturation could be further calculated through a lab developed software. The method proposed in this study offers a new idea for the economic version of the retinal oxygen saturation measurement system. The system is able to measure the oxygen saturation with good accuracy and repeatability, and it has the potential for further study and clinic applications associated with ophthalmic and systemic diseases.

Objective To develop a method for morphological characterizing the 3D-printing porous surgical implants. Methods Micro-CT was employed to get the image data of porous specimen, and MIMICS software was used to analyse the data and realize 3D reconstruction. The porosity, pore diameter, and strut size of porous structure were analysed using internally tangent circle, equivalent circle area method, and inscribed sphere method. The result difference between 2D and 3D images was analysed and compared with the theoretical design parameters, and the results were validated by weight method. Results For regular porous structure, inscribed sphere method could be used to analyse the pore size. For irregular porous structure, the internally tangent circle and area of equivalent circle methods could be used. Conclusion Using Micro-CT plus MIMICS software is an effective method for analysing the morphology characteristics of 3D-printing porous surgical implants.

Objective To explore whether the method of multiscale entropy (MSE) combined with support vector machine (SVM) can effectively detect mental fatigue, and then to compare the detecting performance of electroencephalogram (EEG) electrodes at different cerebral cortex locations. Methods We established the mental fatigue model by continuous cognitive load task, and used a portable device to collect the EEG signals of 12 subjects in the state of waking and mental fatigue, then classified the two states by the MSE and SVM algorithms. Results After the continuous cognitive load task, the fatigue level of the subjects increased significantly, and the NASA-TLX and KSS scales showed significant statistical differences (P<0.01). The average classification accuracy of the two states in frontal lobe Fpz, parietal lobe Pz and occipital lobe Oz EEG electrodes were 92.16%, 81.63% and 90.54%, respectively. There was no statistical difference between Fpz and Oz electrodes (P>0.05), while they showed significant statistical differences when referenced to Pz electrode (P<0.05). Conclusion MSE combined with SVM can effectively detect the waking and mental fatigue state of human body, and Fpz and Oz electrodes can better detect mental fatigue than Pz electrode.

Objective The purpose of this paper was to analyze the characteristics of brain functional network under the influence of frontal lobe epilepsy by resting-state functional magnetic resonance imaging, and to find out the possible evaluation index of brain damage in frontal lobe epilepsy. Methods Typical parameters in graph theory analysis were obtained, including edges, node degree, node efficiency and betweenness centrality. Two-sample t test was carried out for the results in patients with frontal lobe epilepsy and normal controls. The changes of brain functional network under the influence of frontal lobe epilepsy were analyzed to provide evidence for evaluating frontal lobe epilepsy. The correlation analysis of the characteristics with seizure duration and frequency was further conducted. Results Compared with the control group, the frontal lobe epilepsy patients had significant statistical results in the parameters of edge, nodal degree, nodal efficiency and betweenness centrality. Moreover, we found that there were correlations between the results and the frequency and duration of epilepsy. Conclusion The characteristics of resting-state brain functional network based on graph theory analysis may be used as an evaluation index of frontal lobe epilepsy and provide a basis for the evaluation of frontal lobe epilepsy.

In order to increase the degradable degree of biliary stent and improve the situation of easy displacement and biliary restenosis of current biliary stent, a novel degradable biliary stent was designed with TAXOL-P3/4HB-PCL, and the structural parameter were established. A total of 5 diameters of biliary stent were designed according to the size of bile duct for adults and children of different ages. The effect of P3/4HB-PCL on the proliferation of fibroblasts was valued by MTT method. The degradability of P3/4HB-PCL was analyzed by immersing it in PBS buffer. The results showed that P3/4HB-PCL had slight reactivity with fibroblasts, good biocompatibility and good degradability

Objective To reduce the incidence of fault of volumetric infusion pump by developing specific quality control measures based on the analysis of the fault data of volumetric infusion pump. Methods The maintenance records of volumetric infusion pumps in our hospital in the past five years from 2013 to 2017 were collected using the medical equipment management software, and the Laplace transform formula was used to analyze the reliability of the above statistical data and verify the failure trend of volumetric infusion pumps. According to the characteristics of the time distribution and causes of the failure of the volumetric infusion pump, a variety of targeted quality control interventions were conducted and its effect after intervention was observed. Results Laplace’s trend test inferred that the reliability trend of volumetric infusion pumps deteriorated in 2018. Through the development of targeted interventions, the total number of failures of volume infusion pumps decreased by 68% in 2018 compared with 2017, and the time distribution of failures was stable. Conclusion Specific quality control strategy can effectively reduce the failure rate of volumetric infusion pumps and ensure the safety of clinical use of volumetric infusion pumps. This method can also be applied to other medical equipment, providing a reference value for the equipment management department of medical institutions to better combine quality control means to ensure the safety of clinical use of medical equipment.

Objective To strengthen the quality and safety control of ventilator, so as to improve the stability of ventilator and reduce its clinical risk. Methods FLUKE VT650 gas flow analyzer was used to detect the setting values, display values and measured values of five parameters of the ventilator, including tidal volume, respiratory rate, oxygen concentration, inspiratory pressure level, and positive end-expiratory pressure. Results Among the five parameters of 29 ventilators, the error pass rate of ventilation frequency, tidal volume, inspiratory pressure level and positive end-expiratory pressure was 100%, and the oxygen concentration error pass rate was 72.4%. Conclusion Most of the ventilators have been equipped with self-detection function, which can automatically complete the testing and correction work. At the same time, the quality control of the ventilator can be regularly tested to improve its stability and safety, and promote the safe and orderly development of medical work.

Objective To study influence of the slice position on image noise for SIEMENS CT simulator by analyzing the experimental CT image data using the water phantom. Methods The daily quality check program for the SIEMENS Sensation Open CT simulator was utilized for 10 measurements with a water phantom, and the CT images of 6 neighboring slices (S1-S6) were obtained under two conditions of the nominal tube voltages of 120 kV and 140 kV, respectively. Then the values of image noise were obtained by manual delineation with the region of interest. Statistical analysis and comparative study were conducted on the image noise data for different slice positions. Results Under the case with the nominal tube voltages of 120 kV, the values of image noise for the first to sixth slices were (10.73±0.05), (10.66±0.05), (10.58±0.09), (10.58±0.08), (10.72±0.06), and (10.88±0.06) HU, respectively. Under the case with the nominal tube voltages of 140 kV, the corresponding values were (10.09±0.09), (10.02±0.04), (9.90±0.07), (9.93±0.05), (10.1±0.09), (10.17±0.12) HU, respectively. Statistical analysis showed that overall there was statistical difference in image noise at different slice positions. Conclusion The slice position has influence on the image noise of the SIEMENS CT simulator. The values of image noise in the middle slice position are smaller than those in the two ends.

Objective To realize online adaptive radiotherapy of nasopharyngeal carcinoma by the script function of Pinnacle V9.10 planning system without the dynamic planning module. Methods The script function was written and embed. Then, based on SIEMENS Sensation CT and IBA Compass 3D verification system, the transplantation of radiotherapy plan, the transplantation and modification of target volume and organs at risk, the plan evaluation, the generation of new plan and the online dose verification for one patient with nasopharyngeal carcinoma were successively carried out with the involvement of doctors and physicists. Results Four fractions of online adaptive radiotherapy were performed by the combination of script function and manual intervention, with one update of the planning. Conclusion The application of script function can assist workers to achieve online adaptive radiotherapy, but the reoptimization efficiency of online planning and the accurate evaluation of cumulative dose still need to be further solved.

Objective To study the ability of the electrical impedance scanning (EIS) system detecting the changes of breast cancer tissues during the neoadjuvant chemotherapy for breast cancer. Methods A fine breast electrical impedance simulation model was constructed to evaluate the ability of the system detecting changes in size and conductivity of the cancerous tissues during the neoadjuvant chemotherapy. The fitting curves and regression equations were acquired by analyzing simulating data, and the indicators were eventually obtained from the regression equations. Results The ability of the system detecting changes had a linear relationship with both the size and the conductivity of the cancerous tissues. When the system’s detecting threshold value was 0.05, the smallest detectable change of long-diameter of the cancerous tissue was 2.17 mm, and the least detectable conductivity’s change was 0.78 S/m. Conclusion The EIS system enables sensitive detection of changes in size and conductivity of cancerous tissues, and the simulation results can provide theoretical guidance for EIS application in the evaluation of neoadjuvant chemotherapy for breast cancer.

Using computer-aided technology and three-dimensional printing technology, 10 patients with mandibular tumors from a stomatological hospital in Jiangsu Province were operated and the design of the auxiliary guide plate (including mandibular osteotomy guide plate, fibular osteotomy guide plate and mandibular navigation template) was made. It was used to improve the fixing method and structure of mandibular tumors surgical guide plate, improved the conformity of guide plate, and precise surgical operation, so as to meet the anticipated requirements of preoperative plan. The clinical application proved that all patients had successfully completed the operation. The results of the operation were completely consistent with the preoperative plan. No interruption of the operation due to the guide plate problem was found during the operation, and the patients recovered well after the operation. The design and application of digital guide plate improves the safety of mandibular surgery, reduces the complexity of surgery, and effectively assists doctors to complete the operation smoothly. It provides a new idea and method for mandibular tumors surgery

This paper proposes an auxiliary centering system design scheme for intraoperative radiotherapy and verifies its feasibility by model simulation. The auxiliary centering system consisted of a measurement chain and a digital display unit. The measuring chain adopted a multi-joint linkage structure for establishing the spatial positional relationship between the treatment cone and intraoperative radiotherapy machine. The digital display unit employed the single-chip microcomputer to collect the value of the angle sensor at each joint of the measurement chain, and provided the machine head movement parameters required to achieve the centering operation for the operators through calculations. The model simulation indicated that the measurement chain could realize the flexible follow-up of the treatment cone, and the design scheme of the multi-joint linkage structure could be used for the development of the mechanical body of the prototype. Using the head motion parameter solving equation based on DenavitHartenberg method, the head motion parameters required for the centering operation can be accurately calculated. This equation can be used for the software design of the experimental prototype.

According to the national standard GB 9706.27-2005, the accuracy of working data of injection pumps and infusion pumps was tested by balance. The accuracy of infusion equipment was measured by the weighing method. Through data acquisition and processing, horn curve was generated, and percentage errors A and B were calculated. At present, there is no products with high automation degree at home and abroad. This research intended to use a PC computer, a multi-serial card, and Python programming development tools to simultaneously acquire, store, display, process and determine the results of multiple scales in real time. The original record could be printed by one key. This system realizes the closed-loop detection process.

Objective To reduce the working intensity of technicians and reduce the doctor-patient disputes caused by unclear information, a wireless speech broadcast system was designed. Methods The system provided a type of data storage processor based on SD card that established the underlying link based on SPI interface. The read-write operation at FATFS level of SD card was accomplished by MCU through software. The frequent and repetitive sentences in daily work were written, and broadcasted through the loudspeaker box instead of manual work. At the same time, since the wireless radio frequency interface circuit was added, the remote control could be accomplished. Results A total of 12 sets of this system had been purchased by 4 institutes, and its clinical application had proved that it could replace manual notification, improve technicians’ working efficiency and achieve the design purpose. Conclusion This system has clear and loud voice, standard instructions, low cost, remote control, no need to change the X-ray equipment, convenient installation, and good use effect, which is worthy of promotion.

Objective To explore the role and significance of independent dose accounting and dose reconstruction function of Compass system in three-dimensional dose verification of intensity-modulated radiotherapy plan for nasopharyngeal carcinoma. Methods Thirty patients with nasopharyngeal carcinoma were designed for intensive radiotherapy plan, and the dose distribution calculated by the radiotherapy plan system (PD), the patient’s calculated dose distribution (CD) based on the built-in dose plan model: collapsed cone convolution of Compass, the three-dimensional reconstructed dose distribution (RD) by Compass were compared and analyzed in two ways (Group A: PD vs. CD; Group B: PD vs. RD; Group C: CD vs. RD). The Gamma passing rate, D99%, Dmean, D1%, Dmean difference, Pmean of the target area and organs at risk were analyzed. Results In Group A, B and C, the average Gamma passing rate of Globle were more than 97% (3 mm/3% standard), and the relative deviations of D1% and Dmean were less than 2.5%. The Gamma passing rate of globle, GTVnd, parotid, eye, len and temporal lobe in Group B was lower than that in Group A, and the difference was statistically significant (P<0.05). The Gamma passing rate of globle, GTVnd, CTV1, CTV2, parotid, len and temporal lobe in Group B was lower than that in Group C, and the difference was statistically significant (P<0.05). The relative deviations of dose of the target area in Group A, B and C were mostly between 0.8% and 2.5%, and a small part was about 2.7% to 3.2%. The Dmean difference of GTVnd, GTVnx, CTV1, CTV2 and Globle in Group A was statistically significant (P<0.05), except Optical chiasm, the Dmean difference of the other organs at risk in Group C was statistically significant (P<0.05). Conclusion The combination of independent dose accounting and dose reconstruction work of Compass system can provide an effective means for three-dimensional dose verification of clinical radiotherapy plans.