Objective To establish the microvessel model simulation, simulate the movement trajectory of erythrocyte in microvessels, and calculate the relationship between the speed and displacement of erythrocyte and time using the fluid dynamics software COMSOL Multiphysics. Methods According to the reticular structure of the microvascular system, the finite element model was established with COMSOL Multiphysics, and the particle trajectory was processed to obtain stable data analysis results. Results With the increase of flow rate, erythrocyte moved more vigorously and faster. When the flow rate increased from 100 mL/h to 400 mL/h, the average displacement of particles increased from 0.22 cm to 0.84 cm within 1 s, and the relationship between them was not completely linear. Conclusion The simulation of erythrocyte movement in reticular microvascular structure provides valuable information for understanding the mechanism of tissue microcirculation.