As carried out based on the audit knowledge base, and a process closed loop was formed by combining the post-review of the prescription. The implementation of the system effectively stopped unreasonable prescriptions, improved the quality of antibacterial drug management in hospitals, and facilitated the efficient work of outpatient doctors and pharmacists. The hospital, doctors, pharmacists and patients all benefit greatly from the establishment of the pre-examination prescription system of outpatient service to improve the rational drug use in hospitals