Firstly, the status quo of allergy drug management in hospitals was analyzed. Then, aiming at the deficiencies of the existing management model, a set of aller gy drug management system based on the whole process management was established in combination with the allergy drug management norms. Based on HIS systems such as doctor workstation, nurse workstation, pharmacy management system, drug delivery system and mobile infusion system, this system integrated the advantages of clinical auxiliary diagnosis and treatment system and WeChat platform. This system made strict control or early warning of the course of drug administration of allergic drugs by means of information, which ensured absolute safety of drug administration of allergic drugs.