Objective To illustrate the design and realization of the system of host safety based on “No.1 Military Medical Project”. Methods Select the host security protection product SCSP to reset the form of structure and system management, for the security of the system host, host intrusion prevention, intrusion detection, host access control audit and other functions. Results The ability of host to resist invasion improved, access control was stricter and post query was more convenient, which made the host security improve significantly. Conclusions The system provides reference for the host safeguard of local area network in hospitals and other enterprises.