Analysis of Clinical Examination Indicators of Endometrial Atypical Hyperplasia
REN Jian, HAO Yan, LU Dan, LIU Yong
Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University/ Beijing Maternal and Child
Health Care Hospital, Beijing 100026, China
Abstract：Objective To analyze the clinical examination indicators for finding the risk factors and the prediction indicators of the
endometrial atypical hyperplasia (EAH), and provide new ideas for treatment and prevention of this disease. Methods Clinical data of
211 patients who underwent hysteroscopy in the Department of Gynecology from June 2020 to December 2021 at Beijing Obstetrics
and Gynecology Hospital, Capital Medical University were collected. Among them, 107 patients with EAH were the study group and
104 patients with intrauterine adhesion were the control group. The number of pregnancies, menarche age, body mass index (BMI),
laboratory test results, endometrial thickness and uterine volume and so on of the two groups were retrospectively analyzed, and to
explore disease related risk factors and effective diagnostic predictive indicators. Results The values of BMI, platelet
count, low density lipoprotein cholesterol, endometrial thickness and uterine volume in the study group were higher than those in the
control group, and the difference was extremely significant (P<0.001). Triglyceride in study group was higher than in control group,
and the difference was significant (P<0.01). International normalized ratio (INR) and high density lipoprotein cholesterol (HDL-C)
in the study group were lower than those in the control group, and the difference was extremely significant (P<0.001). The number
of pregnancies in the study group was lower than that in control group, and the difference was significant (P<0.05). HDL-C, INR,
endometrial thickness and uterine volume were independent risk factors for EAH (P<0.05), the risk of endometrial thickness was the
highest (OR=5.984). The area under receiver operating characteristic curve of uterine volume in predicting EAH was 0.947 (95%CI:
0.912-0.982), which was better than that of endometrial thickness. Conclusion HDL-C, INR, endometrial thickness and uterine
volume are independent risk factors of EAH, and endometrial thickness has the greatest risk. Uterine volume is the best indicator for
clinical significance in predicting EAH. We should pay more attention to those indicators and delve into diagnostic cutoff values in
order to facilitate the rapid screening and prevention of EAH.
任健，郝焰，卢丹，刘勇. 子宫内膜非典型增生的临床检验指标分析[J]. 中国医疗设备, 2023, 38(7): 139-144.
REN Jian, HAO Yan, LU Dan, LIU Yong. Analysis of Clinical Examination Indicators of Endometrial Atypical Hyperplasia. China Medical Devices, 2023, 38(7): 139-144.
