Changes of Bone Mineral Density in Different Parts of Tibetan Postmenopausal Women at
High Altitude and Its Correlation with Biochemical Indexes
XIE Chun1, LI Zuorui2, SHI Gang1, ZHANG Wuhua1, XIE Luling1, MA Jianping1
1. Department of Imaging, The Fifth People’s Hospital of Qinghai Province, Xining Qinghai 810001, China;
2. Department of Radiology, Qinghai Hospital of Traditional Chinese Medicine, Xining Qinghai 810000, China
Abstract：Objective To analyze the changes of bone mineral density (BMD) in different parts of Tibetan postmenopausal women
at high altitude and its correlation with biochemical indexes. Methods A total of 117 Tibetan postmenopausal women were selected
as the observation group and 29 premenopausal women as the control group. The observation group was divided into normal bone
mass group and osteoporosis group according to the results of BMD. The BMD values of different parts of lumbar L2-L4, femoral
neck, ward triangie and triangle of femur were compared in each group. And the relationship between BMD and the levels of serum
bone specific alkaline phosphatase (ALP), serum Boneglaprotein (BGP), tartrate-resistant acid phosphatase-5b (TRAP-5b), matrix
metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), osteocalcin (OC), amino terminal peptide of type I collagen
(NTx), estrogen (E2), follicle stimulating hormone (FSH), phosphorus (P) and parathyroid hormone (PTH) were analyzed. Results
The BMD values in different parts of normal bone mass group were significantly lower than those in control group (P<0.05).
The BMD value in different parts of osteoporosis group were significantly lower than those in normal bone mass group (P<0.05).
Compared with the control group, serum E2 and P levels in normal bone mass group were significantly decreased, while serum ALP,
BGP, TRAP-5b, MMP-9, NTx, FSH and PTH levels were significantly increased (P<0.05). Compared with normal bone mass group,
serum E2 and P levels in osteoporosis group were significantly decreased, while serum ALP, BGP, TRAP-5b, MMP-2, MMP-9, NTx,
OC, FSH and PTH levels were significantly increased (P<0.05). The BMD values in different parts of osteoporosis group were
negatively correlated with serum ALP, BGP, TRAP-5b, MMP-2, MMP-9, NTx, OC, FSH and PTH (P<0.05), but positively correlated
with serum E2 and P (P<0.05). Conclusion The BMD value of Tibetan postmenopausal women with osteoporosis is significantly
lower than that of premenopausal women. The serum ALP, BGP, TRAP-5b can reflect bone metabolic activity, and the decrease of
BMD value was closely related to the increase of bone turnover rate.
谢春1，李作瑞2，史纲1，张武花1，谢录玲1，马建萍1. 高原藏族绝经后妇女不同部位骨密度的变化规律及其与生化指标的关联性[J]. 中国医疗设备, 2022, 37(7): 144-147.
XIE Chun1, LI Zuorui2, SHI Gang1, ZHANG Wuhua1, XIE Luling1, MA Jianping1. Changes of Bone Mineral Density in Different Parts of Tibetan Postmenopausal Women at
High Altitude and Its Correlation with Biochemical Indexes. China Medical Devices, 2022, 37(7): 144-147.
