Prospect of Nanosecond Pulsed Electric Field for Atrial Fibrillation Treatment
WANG Ling1a, HUANG Qiong1b, SUN Yumei1b, CHEN Yonggang2, WU Bin2, YUAN Yiqiang1b
1. a. Department of Laboratory; b. Department of Cardiology, Henan Provincial Chest Hospital, Zhengzhou Henan 450008, China;
2. Zhejiang Provincial Key Laboratory of Pulsed Power Translational Medicine, Hangzhou Zhejiang 311100, China
摘要导管消融已成为维持心房颤动患者窦性心律的主要治疗方法，肺静脉隔离是最常用的治疗策略。与应用于心房颤
动消融的热能相比，不可逆电穿孔（Irreversible Electroporation，IRE）是一种非热替代方法，在细胞上施加高压场以诱导
细胞膜发生改变，产生纳米孔，从而损害细胞的完整性和生存能力。纳秒脉冲电场消融（Nanosecond Pulsed Electric Field
Ablation，nsPFA）具有通过IRE产生跨壁连续病变的能力，传输到心脏组织的热量较小，并且心肌细胞对电场有超高敏感
性，因此，其具有安全性和有效性。本文总结了nsPFA治疗心房颤动的基本原理和当前的科学证据，并将其与最近的实践
建议进行结合，讨论新兴技术和未来的发展方向。
Abstract：Catheter ablation has become the primary treatment for maintaining sinus rhythm in atrial fibrillation (AF) patients, with
pulmonary vein isolation being the most commonly recommended treatment strategy. Compared with the thermal energy applied
in the ablation of atrial fibrillation, Irreversible Electroporation (IRE) is a non-thermal alternative that exerts a high voltage field to
induce modifications in the cell membrane and creates nanopores, thereby compromising cell integrity and viability. Nanosecond
pulsed electric field ablation (nsPFA) is safe and effective for ablation because of its ability to ablation continuous transwall lesions
through IRE, the small amount of heat transmitted to cardiac tissue, and the ultra-sensitivity of cardiomyocytes to electric fields. This
review summarized the rationale and current scientific evidence for nsPFA treatment of atrial fibrillation and combined it with recent
practice recommendations to address emerging technologies and future directions.
汪领1a，黄琼1b，孙玉梅1b，陈永刚2，吴斌2，袁义强1b. 纳秒脉冲电场消融治疗心房颤动的前景[J]. 中国医疗设备, 2023, 38(5): 61-64.
WANG Ling1a, HUANG Qiong1b, SUN Yumei1b, CHEN Yonggang2, WU Bin2, YUAN Yiqiang1b. Prospect of Nanosecond Pulsed Electric Field for Atrial Fibrillation Treatment. China Medical Devices, 2023, 38(5): 61-64.
