Progress in Liver Tumor Ablation with Nanosecond Pulsed Electric Fields
DU Mengru1,2, MA Ruonan3, JI Zhenyu4, HUA Qianjin5, CHEN Xinhua6,7, ZHUANG Jie2
1. Division of Life Sciences and Medicine, School of Biomedical Engineering (Suzhou), University of Sciences and Technology of
China, Suzhou Jiangsu 215163, China; 2. Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science,
Suzhou Jiangsu 215163, China; 3. Henan Key Laboratory of Ion-beam Bioengineering, School of Agricultural Sciences, Zhengzhou
University, Zhengzhou Henan 450001, China; 4. Department of Medical Electronic Engineering, School of Biomedical Engineering,
Air Force Medical University, Xi’an Shaanxi 710032, China; 5. Department of Interventional Oncology, Taizhou Municipal Hospital,
Taizhou Zhejiang 318000, China; 6. Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang
University School of Medicine, Hangzhou Zhejiang 310003, China; 7. Zhejiang Provincial Key Laboratory of Pulsed Power
Translational Medicine, Hangzhou Zhejiang 311100, China
Abstract：Nanosecond pulsed electric field (nsPEF), as a novel physical means for solid tumor ablation, has received widespread
attention in liver cancer treatment. Currently, it’s at the clinical research stage. Extensive studies have shown that nsPEF can not
only induces apoptosis of liver cancer cells and ablate liver tumors, but also stimulates the innate and adaptive immune response, and
inhibits the recurrence and metastasis of liver tumors. This article reviews the research progress of nsPEF in liver tumor ablation, and
provides an outlook on the issues that still need to be addressed and explored. The aim is to further promote the application of nsPEF
in liver tumor ablation.
杜梦茹1,2，马若男3，季振宇4，华浅近5，陈新华6,7，庄杰2. 纳秒脉冲电场在肝脏肿瘤消融中的研究进展[J]. 中国医疗设备, 2023, 38(5): 49-55.
DU Mengru1,2, MA Ruonan3, JI Zhenyu4, HUA Qianjin5, CHEN Xinhua6,7, ZHUANG Jie2. Progress in Liver Tumor Ablation with Nanosecond Pulsed Electric Fields. China Medical Devices, 2023, 38(5): 49-55.
