Past and Present of Irreversible Electroporation for Tumor Ablation
BAO Jiali1, CHEN Xinhua2,3
1. Research Team of Biophysics and Medical Engineering, Zhejiang Provincial Key Laboratory of Bioelectromagnetics, School
of Medicine, Zhejiang University, Hangzhou Zhejiang 310058, China; 2. Division of Hepatobiliary and Pancreatic Surgery, The
First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou Zhejiang 310003, China; 3. Zhejiang Provincial Key
Laboratory of Pulsed Power Translational Medicine, Hangzhou Zhejiang 311100, China
Abstract：Irreversible electroporation (IRE) is a phenomenon in which irreversible hydrophilic pores are generated in the lipid
bilayer of cell membrane or biological tissue under the action of pulsed electric field, and its biological effect is to cause cell
apoptosis or death. In 2021, the National Food and Drug Administration approved the marketing of two domestic IRE devices. So
far, this technology has been applied in many domestic hospitals for the clinical treatment of liver cancer, pancreatic cancer, prostate
cancer and so on, and achieved good therapeutic effect. This paper reviews the past and present of IRE at home and abroad, and looks
forward to the future development of this technique.
包家立1，陈新华2,3. 不可逆电穿孔肿瘤消融技术的过去和现在[J]. 中国医疗设备, 2023, 38(5): 1-10.
BAO Jiali1, CHEN Xinhua2,3. Past and Present of Irreversible Electroporation for Tumor Ablation. China Medical Devices, 2023, 38(5): 1-10.
