Abstract:Objective To compare the dosimetric difference between static intensity modulated radiation therapy (IMRT) with
fixed jaws in specific field and volumetric modulated arc therapy (VMAT) in patients with breast cancer after radical mastectomy.
Methods A total of 24 patients with breast cancer after radical mastectomy were selected. IMRT plans and VMAT plans were
designed respectively. In the IMRT plans, the supraclavicular area and chest wall area were irradiated by fixed jaw technology in
specific fields. The dose parameters of the target areas and organs at risk, the number of machine units and the verification pass rate
were compared between the two groups. Results The results of CI and HI in target area of the VMAT plan were better than those of
the IMRT plan (P<0.05). The volume parameters in low-dose areas below V5 of contralateral lung in VMAT plan were higher than
those in IMRT plan, while the volume parameters of the high-dose area of the affected lung tissue above V10 was significantly lower
than the IMRT plan(P<0.05). Heart: the parameters of V5 and above in the VMRT plan for patients with left breast cancer were lower
than the IMRT plan. On the other hand, the cardiac parameters of the right breast cancer showed an opposite trend. The average MUs
of the VMAT plan was less than that of the IMRT plan, especially for patients with left breast cancer, with significant difference (t=4.18,
P<0.05). Conclusion For patients after radical mastectomy for breast cancer, both IMRT plan with fixed jaw in specific field and
VMAT plan can meet the clinical needs. The VMAT plan has better target area conformity and uniformity than the IMRT plan, while
reduced exposure volume of the high-dose area in lung tissue and other organ at risk, but increased the irradiated range of the lowdose
area丨 at the same time, decreased MUs and shortened the treatment time.
巩汉顺,孟玲玲,解传滨,谷珊珊,王金媛,杨涛,戴相昆,徐寿平. 乳腺癌根治术后特定射野固定钨门分野静态IMRT与VMAT的临床剂量学评估[J]. 中国医疗设备, 2021, 36(4): 113-118.
GONG Hanshun, MENG Lingling, XIE Chuanbin, GU Shanshan, WANG Jinyuan, YANG Tao, DAI Xiangkun, Xu Shouping. Clinical Dosimetry Evaluation of Static IMRT with Fixed Jaws in Specific Field and
VMAT for Breast Cancer after Radical Mastectomy. China Medical Devices, 2021, 36(4): 113-118.