Abstract：Objective To complete a comprehensive evaluation of the optimized performance and clinical application value of
automatic volumetric modulated arc therapy (A-VMAT) for breast cancer after radical mastectomy based on Auto-planning
technology. Methods A total of 24 patients with breast cancer after radical mastectomy were selected, and Pinnacle3 9.10 plan
system was used to manually design volumetric modulated arc therapy (M-VMAT), the parameters of dose volume histogram were
collected as the optimization parameters of auto-planning to realize the A-VMAT, and then compare the parameters of target and
organ at risk in the two plans, to evaluate the optimization performance of auto-planning technology. Results The CI and HI results
of the A-VMAT plan on the left and right sides were better than those of the M- VMAT plan (t=5.53, -4.42丨 t=3.94, 5.61丨 P<0.05).
Uninfected lung: The volume parameters of V5 and above in A-VMAT plan were lower than those in M-VMAT plan, and only V5 had
statistical differences (t=3.64, 2.32丨 P<0.05)丨 for the affected lung tissue, only V40 was lower than M-VMAT plan. Heart: V2 in A-VMAT
plan of left and right breast cancer patients were higher than those of M-VMAT plan丨 however, all parameters above V5 in right breast
cancer patients showed an opposite trend, and only V20 and V30 showed statistically significant differences (P<0.05). The average MUs
of the A-VMAT plan was less than that of the M-VMAT plan, but there is no statistical difference. Conclusion Compared with M-VMAT
plan, A-VMAT plan has better target dose distribution and lower normal tissue dose for patients with breast cancer after radical
mastectomy.
巩汉顺，解传滨，孟玲玲，王金媛，谷姗姗，杨涛，陈高翔，徐寿平. Auto-planning在乳腺癌根治术后A-VMAT中的优化性能评估及临床应用[J]. 中国医疗设备, 2021, 36(4): 108-112.
GONG Hanshun, XIE Chuanbin, MENG Lingling, WANG Jinyuan, GU Shanshan, YANG Tao,
CHEN Gaoxiang, XU Shouping. Evaluation of Optimization Performance and Clinical Application of
Auto-planning in A-VMAT for Breast Cancer after Radical Mastectomy. China Medical Devices, 2021, 36(4): 108-112.
