Abstract：Objective To explore the correlation between the diagnosis of breast cancer by magnetic resonance imaging (MRI) and the expression of Ki-67 and p53. Methods A total of 120 patients with suspected breast cancer who came to our hospital from March 2016
to March 2019 were enrolled in the study. They were randomly divided into a control group and an observation group (60 people each). Only MRI was used for diagnosis in the control group, while MRI combined with Ki-67 and P53 immunohistological determination
was used for diagnosis in the observation group. The sensitivity and specificity of the two methods for the diagnosis of breast cancer patients were compared. Results The accuracy rate of the examination in the control group was 85.96%, and the accuracy rate of the
observation group was 90.38%. The difference between the two groups was statistically significant (P<0.05). The diagnostic sensitivity of the control group was 80.00% and the specificity was 71.67%. The diagnostic sensitivity of the observation group was 93.33% and
the specificity was 86.67%. There was significant difference between the two groups (P<0.05). The results of Spearman rank correlation analysis on the MRI scores, Ki-67 and P53 in the observation group further found that MRI score was positively correlated with
Ki-67 and P53 (P<0.05). Conclusion MRI score has a positive correlation with the expression of Ki-67 and P53. The combination of the three can improve the accuracy of detection, and significantly improve the sensitivity and specificity of breast cancer diagnosis
徐丽娜aa，唐竹晓a，詹莹莹a，李双标b，戴士林a，马红玉a. 乳腺癌MRI诊断与Ki-67、P53表达的相关性[J]. 中国医疗设备, 2021, 36(1): 90-93.
XU Shaorui, KONG Jie, LOU Wensheng, SU Haobo, ZHOU Chenyao. Correlation between MRI Diagnosis and Expression of Ki-67, P53 in Breast Cancer. China Medical Devices, 2021, 36(1): 90-93.
