Application Researches of Diagnose Lung Nodule by 18F-FDG PET/CT Real-Time
Guidance Percutaneous Lung Biopsy
DENG Yanyun1，XIAO Guoyou2，WANG Guodong1，HUANG Jian1，QIN Lilan1，WEI Jianlin1，Jiang Yanping1，CHAI Hua2
1. Department of Nuclear Medicine, Liuzhou Workers’ Hospital, Liuzhou Guangxi 545000, China|
2. Department of Nuclear Medicine, Guangxi Medical University Affiliated Tumor Hospital, Nanning Guangxi 530021, China
Abstract：Objective To evaluate the applied value of diagnose lung nodule by 18F-FDG PET/CT real-time guidance percutaneous lung biopsy. Methods A paired design was used to group according to conditions such as nodule size, location of the lesion, and 60 patients who were clinically diagnosed as pulmonary nodules were respectively used 18F-FDG PET/CT real-time guided percutaneous lung puncture (multimodal guided method) and routine CT-guided percutaneous lung puncture (conventional method) biopsy, 30 cases in each group. The tissues were send to do the pathology examination after operation. Final diagnosis was established on the basis of postoperative pathology or clinical follow-up more than 12 months. The puncture results of the two methods were compared and analyzed. Results In 60 cases, the puncture target arrival rate in the multimodal guidance group and the conventional group were 100%. The first puncture success rate of the multimodal guided group and the conventional group was 50.00% (15/30) and 16.67% (5/30), respectively. The time taken for successful puncture in the multimodal guided group and the conventional group was (18.26±3.64) min and (19.86±4.19) min, respectively. In the multimodal guided group, the histocytology results of 29 cases of puncture biopsy were consistent with the postoperative pathological or clinical follow-up diagnosis, 1 case was unable to make a pathological diagnosis too little tissue. Among them, 25 cases were diagnosed as malignant tumors, and 4 cases were diagnosed as benign lesions| the coincidence rate of puncture diagnosis was 96.67%. In the conventional group, the histocytology results of 24 cases of puncture biopsy were consistent with the postoperative pathology or follow-up diagnosis after clinical treatment. 5 cases were unable to make a pathological diagnosis due to too little tissue. 1 case was failure due to stoped by the patient with pneumothorax and coughing up blood during puncture. Among them, 18 cases were confirmed malignancy by biopsy, and 6 cases were benign lesions. The coincidence rate of puncture diagnosis was 80.00%. Comparing the puncture operation time and the staying time of the needle in the lung between the two methods, the multimodal guidance method was lower than the conventional method (P<0.05). The complication rate in the multimodal guided group was 6.67% (2/30), and the complication rate in the conventional group was 33.33% (10/30). The multimodal guided group was lower than the conventional group (P<0.05). Conclusion 18F-FDG PET/CT real-time guidance percutaneous lung biopsy can obviously improve one-time success rate, which can effectively reduce the number of needle insertions, shorten operation time, and reduce complications.
