目的 通过比较轻度、中度脊髓型颈椎病及对照组颈髓平均扩散峰度（Mean Kurtosis，MK）值、各向异性分数值 （Factional Anisotropy，FA），探讨扩散峰度成像在轻中度脊髓型颈椎病的应用价值。方法 60例经临床诊断脊髓型颈椎病 患者，根据日本骨科学会17分法（JOA评分）将其分为轻度（13~16分、37例），中度（9~12分、23例），选取对照组20 例，均无明确的神经系统症状及阳性体征，既往无神经系统或影响神经系统的疾病。对所有病例组及对照组行MRI常规平 扫、扩散峰度成像扫描（b值为0、1000、2000；30个扩散方向）。测量受压严重节段脊髓的MK、FA。采用单因素方差分 析方法比较各组间测量参数统计学差异。结果 所有受检者DKI成像显示满意。轻度、中度脊髓型颈椎病患者受压最严重 节段颈髓及对照组颈髓MK值分别为0.83±0.13、0.72±0.11、0.92±0.13，组间比较差异有统计学意义（P<0.05）；FA值 分别为0.64±0.09、0.51±0.12、0.73±0.07，组间比较差异有统计学意义（P<0.05）。FA值与JOA评分相关，R2=0.638， P<0.001；，MK值与JOA评分相关，R2=0.193，P<0.001。结论 用扩散峰度成像评估脊髓型颈椎病，可以反映早期脊髓型颈 椎病脊髓白质和灰质微观病理改变。

Objective To investigate the application value of the mean kurtosis (MK) imaging by comparing the differences of the MK and factional anisotropy (FA) in normal, mild and moderate cervical spondylosis myelopathy patients. Methods Sixty patients diagnosed with cervical spondylotic myelopathy were recruited. In this study according to Japanese Orthopaedic Association (JOA) score, the patients were divided into mild (37 cases scoring between 13 and 16 points) and moderate (23 cases, scoring between 9 and 12 points) groups, and twenty healthy individuals were selected as control. All subjects received routine MRI scans and DKI (diffusion kurtosis imaging) scans (b values selected were: 0, 1000, 2000, thirty directions of diffusion). The mean kurtosis and the factorial anisotropy values were extracted from the most severely oppressed spinal level. Statistical differences were analyzed using analysis of variance. Results Satisfactory DKI image were acquired from all subjects. The MK values extracted from the most oppressed spinal level of mild, moderate, and control group were 0.83±0.13, 0.72±0.11, and 0.92±0.13, respectively, and differences among groups were significant (P<0.05). The FA value of each group were 0.64±0.09, 0.51±0.12, and 0.73±0.07, respectively, and differences among groups were statistically significant (P<0.05). Both the FA value (R2=0.638, P<0.001) and the MK value (R2=0.193, P<0.001) were related to the JOA score. Conclusion DKI may reflect the microscopic pathological changes of white matter and grey matter of spinal cord in early cervical spondylotic myelopathy patients.