Numerical Simulation Irreversible Electroporation Based Tumor Treatment
CHEN Xue, LV Yi, REN Fenggang, WU Rongqian
Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, The First Affiliated Hospital of Xi’an Jiaotong
University, Xi’an Shaanxi 710061, China
Abstract：The application of appropriate pulsed electric field to cells causes irreversible structure changes in cell membrane and
eventually leads cell death. This phenomenon, known as irreversible electroporation (IRE) is emerging as a powerful tool for
non-thermal tumor ablation therapy. Determination of the appropriate parameters to induce maximal damage to the tumor while
sparing surrounding healthy tissue is vital for the success of irreversible electroporation-based cancer treatment. The purpose of this
study herein is to summarize the general numerical simulation strategy of the irreversible electroporation cancer therapy. We first
reviewed the numerical simulation studies on the irreversible electroporation cancer therapy in the past decade, then summarized the
mechanisms of cell death during IRE and the design proposal of irreversible electroporation cancer therapy and finally illustrated the
numerical simulation method of irreversible electroporation cancer therapy by Comsol Multiphysics examples.
