Electrical Impedance Variation Measurement of Rat Ischemic Brain Injuries and Tissue Morphology Control Study
SONG Jia-li1, YANG Lin1, KANG Jun-jun2, LI Hao-ting1, DONG Xiu-zhen1, FU Feng1
1. Faculty of Biomedical Engineering, Fourth Military Medial University, Xi’an Shaanxi 710032, China; 2. School of Basic Medical Sciences, Fourth Military Medial University, Xi’an Shaanxi 710032, China
Abstract：ObjectiveTo study the impedance variation of ischemic stroke and its’ secondary brain edema to distinguish the two types of brain injuries. Methods Two-electrode method was used to measure impedance of rats’ brain in vivo continuously. Then we analyzed the impedance variation over time, and the microscopic morphology parameters were analyzed by Image-Pro Plus as comparison and verification of the impedance variation.ResultsElectrical impedance of rat ischemic brain has risen 10%～20% after 6～8 h of brain ischemia, where the peak of the electrical impedance shows out. Then the impedance reduced over time. And there was a good correlation between the impedance variation and the microscopic morphology parameters.ConclusionBioelectrical impedance measurement technique can be used to distinguish ischemic stroke and secondary brain edema, as indicated by the impedance variation of rat ischemic brain over time.
宋佳丽1，杨琳1，亢君君2，李昊庭1，董秀珍1，付峰1. 在体测量大鼠缺血性脑损伤引起的脑组织电阻抗变化及组织形态学对照研究[J]. 中国医疗设备, 2017, 32(1): 18-21.
SONG Jia-li1, YANG Lin1, KANG Jun-jun2, LI Hao-ting1, DONG Xiu-zhen1, FU Feng1. Electrical Impedance Variation Measurement of Rat Ischemic Brain Injuries and Tissue Morphology Control Study. China Medical Devices, 2017, 32(1): 18-21.
