个体化精准诊疗：临床中的发展与挑战
（上）
张欣然，范应威，廖洪恩
清华大学医学院 生物医学工程系，
北京 100084
Personalized Precision Diagnosis and Therapy: Development and
Challenge in Clinic
ZHANG Xinran, FAN Yingwei,
LIAO Hongen
Department of Biomedical Engineering,
School of Medicine, Tsinghua University,
Beijing 100084, China
摘要 个体化精准诊疗能为重大疾病提供精细化、微创化与高效化的临床诊疗平台，具有巨大的
研究与临床意义。临床精准诊断技术是个体化治疗的关键前提。本文综述了临床领域个体化精准诊
断、信息融合与可视化技术的最新成果与核心方法，对其趋势与挑战的剖析也体现了广阔的发展与
应用前景。个体化精准诊断的持续进步将帮助探寻疾病发生机制，为重大疾病治愈起到关键作用，
同时也将推动临床治疗的发展以及诊断与治疗流程的不断完善，推进智能型微创诊疗一体化。
关键词 ：
个体化精准诊断 ,
高时空分辨率 ,
分子影像 ,
多模态成像 ,
微创诊疗一体化
Abstract ：Personalized precision diagnosis and therapy provide an accurate, minimally invasive and
effective approach for clinical diagnostic and therapeutic platform for complex diseases, which has great
research and clinical value. Accurate diagnosis techniques are important preconditions of personalized therapy. This paper reviewed the most recent achievements and major methods of personalized precision
diagnosis, medical information fusion, and visualization techniques. Developments and challenges of
personalized precision diagnosis and therapy fully reflects its broad prospects in clinical trials. Continued
improvements of personalized precision diagnosis will lead to better understanding of mechanisms of
diseases and will play an important role in the treatment and cure of critical illnesses. Meanwhile it will
also accelerate the trend of integration of intelligent minimal invasiveness diagnosis and therapy.
Key words ：
personalized precise diagnosis high
temporal-spatial resolution
molecular imaging
multimodalities
imaging
minimal invasiveness integrated diagnosis and therapy
收稿日期: 2015-12-22
基金资助: 国家自然科学基金（No.81427803, 61361160417, 81271735）；
北京市科委《生命科学领域前沿技术》专项（No.Z151100003915079）；
“985工程”项目支持。
通讯作者:
廖洪恩
E-mail: liao@tsinghua.edu.cn
作者简介 :
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