Abstract:The high resolution magnetic resource microcopy (MRM) has been widely used in mouse
brain neuroimaging study. The mouth brain template and atlas are the tools essential to the mouse brain
neuroimaging study. The mouth brain is characterized by its small volume and subtle microscopic changes,
which creates difficulty for the establishment of the brain template and atlas. Nowadays many domestic and
overseas’ researchers have focused on setting up different kinds of mouse brain templates. This paper first
introduced the imaging principle and imaging collection methods of MRM and discussed the strategies to
optimize MRM. Secondly, the paper discussed basic elements of the mouse brain template construction, such
as comparison of templates, data acquisition, registration algorithms, and etc. Finally, the paper introduced
the fundamental application of the mouse brain template in the research and treatment of diseases such as
Alzheimer’s disease and Huntington’s disease.
付振荣,林岚,张柏雯,
宾光宇,高宏建,吴水才. 基于MRM的小鼠脑模板创建的研究进展[J]. 中国医疗设备, 2016, 31(2): 25-30.
FU Zhen-rong,
LIN Lan, ZHANG Bai-wen,
BIN Guan-yu,
GAO Hong-jian, WU Shui-cai. Recent Advances in the Research of the Establishment of the MRMbased
Mouse Brain Template. China Medical Devices, 2016, 31(2): 25-30.