呼气检测技术与设备的研究进展
林丽泉，董浩，王福园，陈星
浙江大学
Progress in Technology and Equipment of Exhaled Breath Detection
LIN Li-quan, DONG Hao, WANG Fu-yuan, CHEN Xing
College of Biomedical Engineering and
Instrument Science, Zhejiang University,
Hangzhou Zhejiang 310027, China
摘要 呼吸作为人体重要的生理过程，是人体内环境与外界交换物质的途径之一。呼出气体中包含着大量人体新陈代谢的产物，各项研究表明呼出物的种类和浓度在一定程度上能反映人体健康状态。通过检测呼出气中的标志物能及时诊断人体的健康状态，对疾病的发生、发展过程进行监测，从而达到疾病预防的目的。由于呼气检测的无损性，国内外涌现出了许多呼吸检测技术和设备，本文主要介绍了气体采样、进样及预处理技术与设备，复杂混合气体、特定标识物、呼出气中冷凝物的检测技术和设备的研究进展。
关键词 ：
呼气检测 ,
气体传感器 ,
电子鼻 ,
气相色谱-质谱联用 ,
免疫分析
Abstract ：As an important physiological process for human beings, breathing is one of the most important ways to exchange substances between the human body environment and the outside world. Various studies suggested that the type and concentration of the exhaled breath that contains a large number of metabolic products, have close relationships with human health. Nitric oxide, one kind of exhaled gas, is an internationally recognized molecular markers of airway inflammation. Through detecting the exhaled markers, we can promptly detect the body's health condition, and monitor the occurrence and development of diseases, so as to achieve the purpose of disease prevention. Due to the non-invasive, exhaled breath detection technology and equipment emerged in large numbers both at home and abroad.
Key words ：
exhaled breath detection
gas sensors
electronic nose
gas chromatography mass spectrogra- phy
immunoassay
收稿日期: 2015-11-10
基金资助: 国家自然科学基金项目（No.81201166，No.81571769）；教育部博士点基金项目（No.20120101120165）
通讯作者:
陈星
E-mail: cnxingchen@zju.edu.cn
作者简介 :
diagnosis of human health[J].Trac-Trend Anal Chem,2012,33:1-8.
[1]
Kim KH,Jahan SA,Kabir E.A review of breath analysis for
[2]
Gisbert JP,Pajares JM.Review article:13C-urea breath test in the
diagnosis of Helicobacter pylori infection–a critical review[J].
[3]
Pleil JD,Lindstrom AB.Exhaled human breath measurement
Aliment Pharmacol Ther,2004,20(10):1001-1017.
[2]
Gisbert JP,Pajares JM.Review article:13C-urea breath test in the
diagnosis of Helicobacter pylori infection–a critical review[J].
diagnosis of human health[J].Trac-Trend Anal Chem,2012,33:1-8.
Aliment Pharmacol Ther,2004,20(10):1001-1017.
[3]
Pleil JD,Lindstrom AB.Exhaled human breath measurement
method for assessing exposure to halogenated volatile organic
[3]
Pleil JD,Lindstrom AB.Exhaled human breath measurement
method for assessing exposure to halogenated volatile organic
method for assessing exposure to halogenated volatile organic
compounds[J].Clin Chem,1997,43(5):723-730.
[1]
Kim KH,Jahan SA,Kabir E.A review of breath analysis for
[1]
Kim KH,Jahan SA,Kabir E.A review of breath analysis for
diagnosis of human health[J].Trac-Trend Anal Chem,2012,33:1-8.
Aliment Pharmacol Ther,2004,20(10):1001-1017.
compounds[J].Clin Chem,1997,43(5):723-730.
compounds[J].Clin Chem,1997,43(5):723-730.
[4]
Mendis S,Sobotka PA,Euler DE.Pentane and isoprene in
[4]
Mendis S,Sobotka PA,Euler DE.Pentane and isoprene in
[4]
Mendis S,Sobotka PA,Euler DE.Pentane and isoprene in
expired air from humans:gas-chromatographic analysis of
expired air from humans:gas-chromatographic analysis of
expired air from humans:gas-chromatographic analysis of
single breath[J].Clin Chem,1994,40(8):1485-1488.
single breath[J].Clin Chem,1994,40(8):1485-1488.
[2]
Gisbert JP,Pajares JM.Review article:13C-urea breath test in the
single breath[J].Clin Chem,1994,40(8):1485-1488.
diagnosis of Helicobacter pylori infection–a critical review[J].
[1]
朱俊1 ，陈影1 ，邢昕1 ，王庆保1 ，沙泉2 . 雅培ARCHITECT i2000SR化学发光
免疫分析仪报警数据分析
[2]
刘辉强. 索灵化学发光免疫分析仪故障维修实例
[3]
胡海岩1a ，尹丽娟2 ，张静1a ，冯涛1a ，蒋春林1a ，杜爽1b . Roche Cobas e411电化学发光全自动免疫分析系统性能评估
[4]
王超，赵鹏，曲艳阳，姜伟刚. 样本针清洗站改进的研究
[5]
何文兵1 ，刘先成2 ，周明2 ，杨力1 . 一种小型集成化的荧光免疫分析仪的研究和开发
[6]
林丽泉，王福园，陈星. 呼气检测肺癌的临床应用
[7]
邓田华，余波. Architect i2000sr全自动免疫分析仪故障分析与维修
[8]
王金亮，张鑫，王青江. ARCHITECT i2000SR全自动免疫分析仪常见故障分析
[9]
林翔坤，吴夏青. Architect i2000SR全自动免疫分析仪故障分析处理与预防性保养
[10]
沈增贵，崔飞易，邓红玉. 340 nm波长酶标免疫分析仪的实现
[11]
明道仁，苏大林. Access 2全自动化学发光免疫分析仪原理与维修
