Breath Monitoring of Intravenous Anesthetics Concentration in Blood
DONG Hao1, ZHANG Feng-jiang2, LIN Li-quan1, CHEN Jing1, WANG Fu-yuan1, WANG Ying-ying1, CHEN Xing1
1.College of Biomedical Engineering
and Instrument Science, Zhejiang
University, Hangzhou Zhejiang 310027,
China; 2.Second Affiliated Hospital of
Medical College of Zhejiang University,
Hangzhou Zhejiang 310027, China
Abstract：Propofol accounts for about 70% market share of intravenous anesthetics in clinical surgery. With further research and application of total intravenous anesthesia, precision closed-loop anesthesia is proved to be important in clinical practice. It is necessary to monitor anesthetic dose, assess anesthesia effect, and evaluate anesthesia prognosis in a rapid and comprehensive way during the closed-loop anesthesia. Due to intravenous injection of anaesthetic, the difficulty to precisely monitor anaesthetic dose in blood has become the main limit for development of precision closed-loop anesthesia. In recent ten years, propofol detection using real-time breath monitoring developed rapidly with novel techniques and methods, which might break through the barrier of the closed-loop anesthesia. This study presents systems and methods using synchronized applications of gas chromatograph (GC) and surface acoustic wave (SAW) sensor for on-line monitoring of propofol in exhaled gas. SPME-GC-MS was used to calibrate to GC-SAW sensor system for verifying feasibility, reliability, detection limit, and linearity. The propofol concentrations in exhaled gas was compared with concentrations in blood calculated by target-controlled infusion (TCI). The results showed a high degree of consistency. In conclusion, GC-SAW system was proved to be a reliable way for clinical monitoring of propofol concentration through patients’ exhaled gas.This detection system would reduce the side effects of propofol intravenous anesthesia during surgery.
董浩1，张冯江2，林丽泉1，陈璟1，王福园1，王莹莹1，陈星1. 呼出气监测静脉麻醉药血药浓度[J]. 中国医疗设备, 2016, 31(2): 18-20.
DONG Hao, ZHANG Feng-jiang, LIN Li-quan, CHEN Jing, WANG Fu-yuan, WANG Ying-ying, CHEN Xing. Breath Monitoring of Intravenous Anesthetics Concentration in Blood. China Medical Devices, 2016, 31(2): 18-20.
