Abstract：Objective To explore the effectiveness of application of combination of Mimics software and rapid prototyping technology in pedicle screw fixation. Methods With application of combination of Mimics software and rapid prototyping technology, the atlanto-axial model and the screw-guiding device were designed and made. Eleven patients with atlanto-axial vertebral fractures were selected as Experiment Group and underwent pedicle screw fixation under the guidance of the screw-guiding device. Another 20 patients who had been treated with traditional pedicle screw fixation were involved in this research as Control Group so as to make a comparison of the therapeutical effect between two groups. Results The acceptable rate for patients in Experiment Group was 100% versus 87.5% in Control Group with statistically significant differences (P<0.05). The Experiment Group showed remarkably higher postoperative JOA score than Control Group with statistically significant differences (P <0.05). Conclusion The screw-guiding device that was made by using the Mimics software in combination with the rapid prototyping technology could be utilized to provide guidance for patients with atlanto-axial vertebral fractures during pedicle screw fixation, which had proven itself with excellent therapeutical outcome.
