Rapid Health Technology Assessment of Heavy-Ion Radiation System for Tumor Treatment
ZHANG Chen1, GE Yue2, WEI Yan2, TIAN Dan1,2, YANG Yi2, CHEN Yingyao2
1. Department of Logistics, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University,
Shanghai 200127, China; 2. Key Lab of Health Technology Assessment, National Health Commission, School of Public Health,
Fudan University, Shanghai 200032, China
Abstract：Objective To evaluate the safety, effectiveness and economic study of heavy-ion radiotherapy, and to provide reference
for scientific and rational equipment allocation. Methods The rapid health technology assessment method was used to search the
international HTA database, CBM, CNKI, PubMed and other Chinese and English journal literature databases by PICOS. AMSTAR2
and CHEERS were used to quality assessment and inductive analysis of the included literature. Results As of July 2023, there were
approximately 13 active heavy ion radiotherapy centers worldwide. A total of 10 literature related to the safety and effectiveness
of heavy-ion radiotherapy system was searched and included in this study. The medium-quality evidence showed that compared
with traditional photon radiotherapy and proton therapy, the existing evidence was insufficient to demonstrate the advantages and
disadvantages of heavy ion radiotherapy in patients with head and neck tumors, nasal/sinus tumors, adenoid cystic salivary gland
carcinoma, non-small cell lung cancer and prostate cancer. A total of 5 literature related to economic study was included in the search,
and high quality evidence showed that heavy ion radiotherapy and stereotactic radiotherapy were superior to proton radiotherapy and
traditional radiotherapy for non-operable non-small cell lung cancer. Conclusion At present, there are limited studies on the costeffectiveness
of heavy ion radiotherapy, and there is a lack of local economic study in China. The key to future exploration is more
in-depth research and multi-center randomized trials to promote the continuous progress and wide application of this technology.
张晨1，葛悦2，魏艳2，田丹1,2，杨毅2，陈英耀2. 重离子放射系统治疗肿瘤的快速卫生
技术评估[J]. 中国医疗设备, 2024, 39(4): 88-95.
ZHANG Chen1, GE Yue2, WEI Yan2, TIAN Dan1,2, YANG Yi2, CHEN Yingyao2. Rapid Health Technology Assessment of Heavy-Ion Radiation System for Tumor Treatment. China Medical Devices, 2024, 39(4): 88-95.
