Application of Nanoscale Metal-Organic Frameworks (nMOF) in PET and Tumor Therapy
WEI Kejun1,2, XUE Changguo1
1. School of Materials Science and Engineering, Anhui University of Science and Technology, Huainan Anhui 232001, China;
2. Department of Materials and Equipment, Chaohu Hospital of Anhui Medical University, Hefei Anhui 238000, China
Abstract：Objective To analyze the application of 89Zr-UiO-66/Py-PGA-PEG-F3 in the treatment of cancer by using positron emission
tomography (PET) imaging method, so as to explore the significance of 89Zr-UiO-66/Py-PGA-PEG-F3 in PET imaging and tumor
therapy. Methods The intrinsic radioactive UiO-66 nanoscale metal-organic frameworks (nMOF) (89Zr UiO-66) doped with positron
emission isotope zirconium-89 (89Zr) was synthesized and analyzed. 89Zr-UiO-66 was further functionalized with pyrene-derived
polyethylene glycol (Py-PGA-PEG) and conjugated with a F3 peptide to nucleolin for targeting of triple-negative breast tumors.
Doxorubicin (DOX) was loaded into UiO-66 with a relatively high loading capacity (1 mg DOX/mg UiO-66) and served as both a
therapeutic cargo and a fluorescence visualizer. The effects of three different pH values on DOX release were selected.
Results Functionalized 89Zr-UiO-66 demonstrated strong radiochemical and material stability in different biological media. Based on
the findings of cellular targeting and in vivo PET imaging, the typical coronal PET images of MDA-MB-231 tumor-bearing mice
at different time points after injection of 89Zr-UiO-66/Py-PGA-PEG-F3, 89Zr-UiO-66/Py-PGA-PEG-PEG and 89Zr-UiO-66/Py-
PGA-PEG-F3 + blocking dose F3 peptide (10 mg/kg mouse body weight) could clearly identify the targeting of nucleolin.
Conclusion 89Zr-UiO-66/Py-PGA-PEG-F3 can be used as a nanoscale platform for PET imaging guide and tumor selective
cargo delivery. By selectively targeting the tumor vasculature and tumor cells with nuclein, this intrinsic radioactive nMOF can
be widely used in cancer therapeutics.
魏柯君1,2，薛长国1. 金属有机框架纳米材料在PET成像和肿瘤
治疗中的应用研究[J]. 中国医疗设备, 2024, 39(3): 139-145.
WEI Kejun1,2, XUE Changguo1. Application of Nanoscale Metal-Organic Frameworks (nMOF) in PET and Tumor Therapy. China Medical Devices, 2024, 39(3): 139-145.
