Prediction of Radiation Pneumonia in Non-Small Cell Lung Cancer by DWI Before
Radiotherapy and the Change of Apparent Diffusion Coefficient After Radiotherapy
YANG Baolong1, BIAN Yan2, GUO Dongdong1
1. Department of Oncology, Yan’an People’s Hospital, Yan’an Shaanxi 716000, China;
2. Department of Obstetrics, Yan’an University Affiliated Hospital, Yan’an Shaanxi 716000, China
Abstract：Objective To explore the prediction of radiation pneumonia in non-small cell lung cancer by diffusion weighted imaging
(DWI) before radiotherapy and the change of apparent diffusion coefficient (ADC) after radiotherapy. Methods The clinical data
of 120 patients with stage Ⅲ and Ⅳ non-small cell lung cancer treated in our hospital from February 2019 to February 2021 were
retrospectively selected. According to the occurrence of radiation pneumonia after radiotherapy, the patients were divided into RP
group (n=35) and Non-RP group (n=85). The general data, ADC data of DWI before radiotherapy and ADC data of DWI after
radiotherapy were compared with groups, and the changes of ADC in the two groups were evaluated by random walk model.
Results There were differences in average ADC1 value, ADCmax and ADCmin values between the two groups before radiotherapy
(P<0.05). The average ADC1 value of patients before radiotherapy predicted the area under curve of radiation pneumonia of nonsmall
cell lung cancer was 0.862 (95%CI: 0.761~0.934, P<0.01), the sensitivity was 95.17%, the specificity was 77.65%, and the
best cut-off point was 1.42×10-3 mm2/s. The ADC values were increased in all patients after radiotherapy. There were significant
differences in average ADC2 value, ΔADC1 value at 1 week, ΔADC2 value at 4 week, ΔADC3 value at 8 week and ΔADC4 value
at 6 months after radiotherapy between the two groups. The change of ADC before and after radiotherapy in Non-RP group was
more significant than that in RP group. The results of random walk model showed that Non-RP group had a better effect on the
improvement of the above-mentioned indexes. Conclusion DWI in patients with stage Ⅲ and Ⅳ non-small cell lung cancer before
radiotherapy revealed that the ADC value of patients with non-small cell lung cancer after radiotherapy was significantly higher than
that before radiotherapy, and the ADC value of patients without radiation pneumonia was more significant.
杨宝龙1，边燕2，郭东栋1. 放疗前弥散加权成像预测非小细胞肺癌放
射性肺炎及放疗后表观弥散系数值改变[J]. 中国医疗设备, 2023, 38(4): 149-154.
YANG Baolong1, BIAN Yan2, GUO Dongdong1. Prediction of Radiation Pneumonia in Non-Small Cell Lung Cancer by DWI Before
Radiotherapy and the Change of Apparent Diffusion Coefficient After Radiotherapy. China Medical Devices, 2023, 38(4): 149-154.
