Value of Shear Wave Elastography Combined with C-TIRADS Guidelines in the Differential
Diagnosis of Thyroid Nodules
XU Ke, SHI Bo, DENG Nan, DU Jun, LIU Jiakai
Department of Ultrasound Medicine, The 2nd Affiliated Hospital of Chengdu Medical College Nuclear Industry 416 Hospital,
Chengdu Sichuang 610041, China
Abstract：Objective To explore the value of shear wave elastography (SWE) combined with Chinese Thyroid Imaging Reporting
and Data System (C-TIRADS) classification guidelines in the differential diagnosis of thyroid nodules. Methods The data of 176
patients with thyroid nodules were retrospectively analyzed, with a total of 179 nodules, including 78 benign nodules and 101
malignant nodules. There were 77 small nodules (≤10 mm) and 102 large nodules (>10 mm). With crude needle puncture or surgical
pathological results as the “gold standard”, the consistency between conventional ultrasonic C-TIRADS classification diagnosis,
SWE and their combined diagnosis and “gold standard” was analyzed, and the working characteristic curve of subjects was drawn to
analyze the diagnostic efficacy of conventional ultrasonic C-TIRADS classification diagnosis, SWE and their combined diagnosis.
Results The maximum value (SWEmax), the minimum value (SWEmin), the mean value (SWEmean) and the standard deviation (SWESD)
of SWE Young's modulus of benign nodules were smaller than those of malignant nodules, and the difference was statistically
significant (P<0.05). With regard to malignant nodules, the SWEmax, SWEmean, SWEmin, and SWESD values of the large nodule group
were higher than the small nodule group, and the difference was statistically significant (P<0.001). The sensitivity, specificity,
accuracy, area under curve (AUC) and Kappa values of C-TIRADS guideline diagnosis were 97.03%, 60.26%, 81.0%, 0.786 and
0.597, respectively. The sensitivity, specificity, accuracy, AUC, and Kappa values of SWE diagnosis were 89.11%, 87.18%, 88.3%,
0.881 and 0.762, respectively. The kappa value, sensitivity, specificity, accuracy,and AUC of the combined diagnosis were 0.874,
99.01%, 88.46%, 94.4%, and 0.937, respectively. Conclusion Young’s modulus values of large and small malignant nodules were
higher than those of large and small benign nodules. The combination of SWE and C-TIRADS guidelines in the diagnosis of thyroid
nodules can further improve the sensitivity, specificity, accuracy, which can be extended to clinical practice.
徐可，石波，邓楠，杜君，刘家开. 实时剪切波弹性成像定量参数
结合C-TIRADS指南在甲状腺
结节鉴别诊断中的价值[J]. 中国医疗设备, 2023, 38(3): 78-82.
XU Ke, SHI Bo, DENG Nan, DU Jun, LIU Jiakai. Value of Shear Wave Elastography Combined with C-TIRADS Guidelines in the Differential
Diagnosis of Thyroid Nodules. China Medical Devices, 2023, 38(3): 78-82.
