Study on the Resting Low Frequency Amplitude fMRI of Abnormal Spontaneous Brain
Activity in Patients with Postpartum Depression
LI Bo1, ZHANG Shufen2, CHEN Chunlian3, WANG Yunjia2, LIU Tengwei2, LIU Kai1, SUN Gang1、
1. Department of Radiology, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan Shandong 250031, China;
2. Department of Obstetrics, Shandong Second Provincial General Hospital, Jinan Shandong 250022, China; 3. Graduate Training
Base, The 960th Hospital of PLA Joint Logistic Support Force of Jinzhou Medical University, Jinan Shandong 250031, China
Abstract：Objective To explore abnormal spontaneous neuronal activity in patients with postpartum depression (PPD) under
amplitude of low frequency fluctuation (ALFF). Methods Resting-state functional MRI data of 35 PPD patients (PPD group) and 34
healthy postpartum women (HPW group) were collected, the differences in ALFF values between the two groups were compared by
the independent sample t test, and the correlation between the Edinburgh Postnatal Depression score (EPDS) and the abnormal mean
ALFF values of the brain regions in PPD patients was analyzed. The receiver operating characteristic (ROC) curve analysis was used
to judge the diagnosis value of the brain regions with abnormal ALFF. Results Compared with the control group, PPD group showed
decreased ALFF values in the anterior cingulate, posterior cingulate cortex. PPD group had increased ALFF values in the insula,
superior temporal cortex, there was no correlation between their ALFF values and EPDS. The area under the ROC curve of each brain
area with abnormal ALFF in PPD was above 0.83. Conclusion There are abnormal changes in the functions of brain regions related
to default network, salience network and central executive network in patients with PPD. The brain areas with abnormal ALFF have
appropriate diagnosis values, which provides imaging references for understanding the pathogenesis of PPD.
李勃1，张书芬2，陈春莲3，王云嘉2，刘腾微2，刘锴1，孙钢1. 产后抑郁症患者大脑自发活动异常的静息态低频振幅fMRI研究[J]. 中国医疗设备, 2022, 37(12): 73-76.
LI Bo1, ZHANG Shufen2, CHEN Chunlian3, WANG Yunjia2, LIU Tengwei2, LIU Kai1, SUN Gang1、. Study on the Resting Low Frequency Amplitude fMRI of Abnormal Spontaneous Brain
Activity in Patients with Postpartum Depression. China Medical Devices, 2022, 37(12): 73-76.
