Correlation Between 18F-FDG PET/CT Parameters and PD-L1 Expression in Lung Cancer
WANG Guanmin1, ZHUO Jing2, ZHU Feng1, LIU Defeng1, DING Xuemei1, XU Yaping1, MENG Tao1
1. Department of Nuclear Medicine, Xuzhou Central Hospital, Xuzhou Jiangsu 221000, China;
2. Department of Pathology, Xuzhou Cancer Hospital, Xuzhou Jiangsu 221000, China
Abstract：Objective To analyze the correlation between the standardized uptake value (SUVmax) , metabolic tumor volume (MTV),
total lesion glycolysis (TLG) of 18F-fludeoxyglucose positron emission computed tomography/computed tomography (18F-FDG PET/
CT) semiquantitative parameters and the expressions of programmed cell death-1 ligand 1(PD-L1) in cancer tissues.
Methods The clinical data of 90 patients with lung cancer (study group) and 82 patients with benign lung disease (control group)
admitted to our hospital from June 2018 to May 2021 were analyzed retrospectively. 18F-FDG PET/CT examination was performed in
both groups, and the expressions of PD-L1 in the cancer tissues and adjacent tissues of the study group, and benign tumor tissues of
the control group after tumor resection were detected. The SUVmax value, MTV and TLG of 18F-FDG PET/CT quantitative parameter
as well as the expressions of PD-L1 in the cancer tissues, in the two groups were compared. The correlations between SUVmax value,
MTV, TLG and the expression of PD-L1 in cancer tissues were analyzed. Results The SUVmax value, MTV and TLG of 18F-FDG
PET/CT quantitative parameter in the study group were higher than those of the control group, the SUVmax value, MTV and TLG
of lung squamous cell carcinoma were higher than those of lung adenocarcinoma, the expression of PD-L1 in the cancer tissues of
the study group was higher than those in the adjacent tissues and benign tumor tissues, the difference was statistically significant
(P<0.05); and the expression of PD-L1 in benign tumor tissues was higher than that in adjacent tissues (t=12.098,P<0.001); the
expression of PD-L1 in lung squamous cell carcinoma was lower than that in lung adenocarcinoma, the difference was statistically
significant (P<0.05); the SUVmax value, MTV and TLG of 18F-FDG PET/CT quantitative parameter in the study group were positively
correlated with the expression of PD-L1 in cancer tissues (P<0.05), and the results of lung squamous cell carcinoma and lung
adenocarcinoma were consistent with the above (lung squamous cell carcinoma: r=0.769, 0.878, 0.905, P=0.012, 0.005, <0.001; lung
adenocarcinoma: r=0.744, 0.815, 0.846, P=0.030, 0.019, 0.010). Conclusion The SUVmax value, MTV and TLG of 18F-FDG-PET/
CT quantitative parameters and the expression of PD-L1 in lung cancer were higher than those in adjacent tissues and benign tumor
tissues, and the 18F-FDG PET/CT parameters were positively correlated with PD-L1 expression in cancer tissues.
