Study on the Arterial Transit Time in the 3D Arterial Spin Labeling Technique
WANG Zheng1, FU Xue-mei2, ZENG Xiang-zhu1, LIU Ying1, YUAN Hui-shu1
1.Department of Radiology, Peking
University Third Hospital, Beijing
100198, China; 2.School of Bio-Medical
Engineering, Peking University, Beijing
100871, China
Abstract：Objective To determine the arterial transit time (ATT) in 3D pseudo continuous arterial spin labeling (3D pcASL) imaging and analyze its relevance with the reduction of cerebral blood flow (CBF) in patients with Blzheimer's disease (AD). Methods Conventional MR and pcASL 3D perfusion imaging were performed in 12 patients with AD (AD Group) and 17 age-matched normal subjects (Control Group). The SPM 8 software was used to pre-process the ATT images and compare the differences between the two groups so as to evaluate the correlation between the ATT value and reduction of CBF in the encephalic region with increased ATT. Results The increased ATT area in AD Group mainly occurred in the left insula and left inferior frontal gyrus, left superior temporal gyrus and middle temporal gyrus, bilateral posterior cingulate gyrus, bilateral precuneus, left parahippocampal back (t=2.4727, P<0.001). Conclusion The ATT value in the decreased perfusion area was correlated with the decrease of cerebral blood flow perfusion.
王筝，傅雪梅，曾祥柱，刘颖，袁慧书. 基于3D动脉自旋标记技术核磁灌注成像中动脉通过时间的研究[J]. 中国医疗设备, 2015, 30(9): 24-26.
WANG Zheng, FU Xue-mei, ZENG Xiang-zhu, LIU Ying, YUAN Hui-shu. Study on the Arterial Transit Time in the 3D Arterial Spin Labeling Technique. China Medical Devices, 2015, 30(9): 24-26.
