Functional Connectivity in Patients with Traumatic Brain Injury Based on
Resting-State Functional Magnetic Resonance Imaging
FAN Xiabing1,2, YANG Li2, ZHANG Hehua2, LI Zhangyong1, WANG Wei1
1. School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China;
2. Department of Medical Engineering, Daping Hospital of Army Military Medical University, Chongqing 400042, China
Abstract：Objective To explore the functional connection in patients with traumatic brain injury (TBI) based on resting-state
functional magnetic resonance imaging (rs-fMRI). Methods The rs-fMRI images of 14 TBI patients and 12 healthy controls (HC)
were preprocessed by independent component analysis (ICA) gets default model network (DMN) and executive control network
(ECN), four brain regions were selected from each of the two brain networks as seed points for functional connection analysis.
Finally, one-sample t-test, two-sample t-test and paired t-test were used to explore the differences and changes of functional
connectivity between DMN and ECN at 3, 6 and 12 months after TBI injury compared with HC group. Results The functional
connections of TBI patients at three time points during the recovery period were significantly different from that of HC group, and
the functional connectivity between DMN and ECN network was more obvious than that within a single network. In addition, the
left parietal lobe was a key node, which may provide a new direction for the subsequent treatment of TBI. Conclusion There are
significant abnormalities in the functional connection between DMN and ECN in the resting brain network of patients after TBI,
which may be the cause of long-term cognitive impairment and other sequelae.
范夏冰1,2，杨利2，张和华2，李章勇1，王伟1. 基于静息态功能磁共振成像的创伤性脑损伤患者功能连接研究[J]. 中国医疗设备, 2022, 37(6): 23-28.
FAN Xiabing1,2, YANG Li2, ZHANG Hehua2, LI Zhangyong1, WANG Wei1. Functional Connectivity in Patients with Traumatic Brain Injury Based on
Resting-State Functional Magnetic Resonance Imaging. China Medical Devices, 2022, 37(6): 23-28.
