1. a. National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine; b. Department of
Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an Shaanxi 710061, China; 2. Institute of
Electrical Science and Technology Research, Xi’an Jiaotong University, Xi’an Shaanxi 710049, China
Abstract:Based on the principle of biological effect of pulsed electric field, high-voltage electrical pulses (HVEP) technique is a new
type of non-thermal local treatment, which has the characteristics of electric field-dependent, non-thermal damage and controllable
range of action. The HVEP technique is currently mainly used in non-thermal food sterilization, cell electrofusion, gene transfection,
electrochemotherapy, cardiac electro physiotherapy and tumor ablation. In recent years, with the deepening of basic and application
research of this technology, more and more novel technologies and devices based on the HVEP are coming into clinical practice. This
review summarized the research and application progress of HVEP technique in the field of tumor treatment and analyzed the future
development of this technology.