Abstract：Objective To discuss the basic problems of hematoxylin as an exogenous MR spectroscopic biomarker
in tumor molecular imaging. Methods Different concentrations of hematoxylin solutions were performed
high-field MR spectroscopy with the methods of Point Resolved Spectroscopy (PRESS) and Stimulated Echo
Acquisition Mode (STEAM) respectively. Then the MR spectroscopy signal features of different concentrations
of hematoxylin which was performed with different scanning methods were analyzed. Results The results
showed that the specific MR spectroscopy signal profile of hematoxylin could be detected with both methods
of PRESS and STEAM. The peak position was stable, while the peak height and peak area were related with
the concentration of hematoxylin solution, the higher the concentration was, the more salient the specific MR
spectroscopy signal profile was. Conclusion It was found that the hematoxylin has specific MR spectroscopic
signal, which might make it a potential exogenous MR spectroscopic biomarker in tumor molecular imaging.
霍天龙，杨硕，陈雷，康钰，陈尘. 苏木素作为外源性波谱标志物进行肿瘤MRS分子成像的初步研究[J]. 中国医疗设备, 2017, 32(3): 1-5.
HUO Tian-long, YANG Shuo,
CHEN Lei, KANG Yu, CHEN Chen. Hematoxylin as an Exogenous MR Spectroscopic Biomarker in Tumor
Molecular Imaging: A Pilot Study. China Medical Devices, 2017, 32(3): 1-5.
