摘要主要介绍了利用CT技术判断冠状动脉周围脂肪组织在炎症因子的作用下表型变化的机理，脂肪细胞是在炎症因子
影响下，发生细胞内脂质减少、水分增加，且其密度也相应增加，应用CT技术通过离体和在体研究，证实了冠状动脉周围
脂肪CT衰减指数（Fat Attenuation Index of Peri-Coronary，Pc-FAI）可显示脂肪表型的变化，即炎症状态越严重，Pc-FAI越
高。将Pc-FAI作为冠状动脉粥样硬化炎症状态的影像生物学指标相关研究显示，Pc-FAI可用于对高危斑块识别、冠心病危
险分层、抗炎治疗效果评估等。
Abstract：This article mainly reviewed the mechanism of using CT to judge the phenotypic changes of adipose tissue around coronary artery under the affection of inflammation. Under the influence of inflammatory factors, the intracellular lipids decreased
and water content increased, and fat tissue density has increased accordingly. Through in vitro and in vivo studies using CT, it
has been confirmed that the fat attenuation index of peri-coronary (Pc-FAI) could show the change of fat phenotype, that was, the
heavier the inflammatory state, the higher the Pc-FAI. Studies on Pc-FAI as an imaging biological indicator of inflammatory status
of coronary atherosclerosis have shown that Pc-FAI can be used to identify high-risk plaque, classify coronary heart disease risk, and
evaluate the effect of anti-inflammatory treatment.
金鑫，张兴华，杨立. CT测量冠状动脉周围脂肪炎症的
机理及应用进展[J]. 中国医疗设备, 2022, 37(8): 3-7.
JIN Xin, ZHANG Xinghua, YANG Li. Mechanism and Application Progress of CT Measurement of Peri-Coronary Fat Inflammation. China Medical Devices, 2022, 37(8): 3-7.
