Abstract：Objective To investigate the quantitative evaluation value of multi-phase dynamic gadolinium ethoxybenzyl
diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced MRI in the staging of chronic hepatitis B liver fibrosis. Methods A total
of 86 patients with chronic hepatitis B who underwent 3.0 T MR examination were enrolled, including 25 patients with stage
1 (S1), 18 patients with stage 2 (S2), 23 patients with stage 3 (S3), and 20 patients with stage 4 (S4). The signal intensity (SI) values of
liver parenchyma in plain scan, arterial phase, portal phase, transition phase and 20 min hepatobiliary phase were measured, and
the relative enhancement rate (REAP, REPV, RETP, REHBP) and contrast enhancement index (CEIAP, CEIPV, CEITP, CEIHBP) of the liver
parenchyma during arterial phase (AP), portal phase (PV), transition phase (TP) and 20 min hepatobiliary phase after enhancement
were calculated. Kruskal-Wallis H test was used to quantitatively evaluate the value of the relative enhancement rate and the contrast
enhancement index for the S1-S4 staging of liver fibrosis after enhancement, and the ROC curve was used to evaluate the multistage
enhancement quantitative parameters in the diagnosis of liver fibrosis in stage 2 or greater (≥S2), stage 3 or greater (≥S3) and
S4. Results The relative enhancement rate of different liver fibrosis stages (S1-S4) showed statistically significant difference, and
REPV, RETP, CEITP and CEIHBP values decreased successively with the increase of liver fibrosis stages. CEIHBP had a higher diagnostic
efficiency than RETP and CEITP in different liver fibrosis stages (≥S2, ≥S3 and S4). The areas under the curve were 0.775 (95%CI:
0.672-0.858), 0.765 (95%CI: 0.662-0.850), 0.821 (95%CI: 0.723-0.895), respectively, and REPV had the lowest diagnostic efficiency.
Conclusion RETP, CEITP and CEIHBP in liver parenchyma after multi-phase dynamic Gd-EOB-DTPA enhancement have certain
diagnostic value in quantitative evaluation of liver fibrosis stage, and CEIHBP has the best diagnostic efficiency.
