Dignostic Value of DCE-MRI Quantitative Parameters in Prostate Disease and the
Association of Gleason Score in the Pathology of Prostate Cancer
ZHOU Hongmei, XU Xiangyang, LI Ying, LIU Xiang, YANG Jian, HUANG Dezhen
Department of Radiology, Liyuan Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology,
Wuhan Hubei 430070, China
Abstract:Objective To explore the value of dynamic enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters
in the differential diagnosis of prostate cancer and prostatic hyperplasia, and to understand the correlation between quantitative
parameters and pathological Gleason score of prostate cancer. Methods A total of 156 cases (61 prostate cancer and 95 prostatic
hyperplasia) were treated with DCE-MRI. The mean, standard deviation and percentile and variance analysis of the quantitative
parameters were analyzed. Meanwhile, the association of quantitative parameters of DCE-MRI in prostate cancer and pathologic
Gleason score was analyzed. Results Compared with the prostate hyperplasia group, the average, standard deviation, 50%, 75%,
and 90% of the Ktrans, Ve and Vp in prostate cancer group were significantly higher (P<0.01) than that of benign prostate prostatic
hyperplasia group. The Kep value of the prostate cancer group was significantly reduced by 10%, and the accuracy rate was the
highest when the Kep value was in 10th percentile. The sensitivity was 66.7% and the specificity was 72.7%, if the Kep value was
10% lower than that of prostate cancer. Linear correlation and regression analysis showed that the parameters of DCE-MRI in prostate
cancer group were in linearly dependent on the parameters of Ktrans and Ve on Gleason’s. Conclusion DCE-MRI can quantitatively
reflect the distribution and perfusion of microvascular in prostate. Multiple quantitative parameters can be applied to the differential
diagnosis of prostate cancer and prostatic hyperplasia, and multiple quantitative parameters have linear correlations with the
Gleason’s score in the pathology of prostate cancer, and can reflect the tumor grade and stage.
周红梅,徐向阳,李莹,刘祥,杨建,黄德珍. DCE-MRI定量参数在前列腺病变诊断中的价值及与Gleason评分的相关性[J]. 中国医疗设备, 2018, 33(5): 71-75.
ZHOU Hongmei, XU Xiangyang, LI Ying, LIU Xiang, YANG Jian, HUANG Dezhen. Dignostic Value of DCE-MRI Quantitative Parameters in Prostate Disease and the
Association of Gleason Score in the Pathology of Prostate Cancer. China Medical Devices, 2018, 33(5): 71-75.