Abstract:Cognitive reserve interprets individual differences in susceptibility to deterioration of cognitive functions
in the dementia and other brain degradation of brain substance. Traditionally, cognitive reserve is estimated
indirectly by measuring static proxy variables. Imaging studies have shown that subjects with neurodegenerative
disease have higher brain age gap estimation (BrainAGE) scores due to advanced brain ageing. The present study
extends BrainAGE to evaluate cognitive reserve on a cohort of 72 healthy older adults who underwent several
neuropsychological tests and structural magnetic resonance imaging (MRI). The result showed that people with
lower BrainAGE scores are more resilient than others. These suggest that changes in BrainAGE may capture how
brain network dynamically adapts itself to compensate brain damage, and BrainAGE could be an alternative proxy
for cognitive reserve than other static cognitive reserve proxies.
林岚,张柏雯,吴水才. 脑年龄估值差对健康老龄大脑认知储备的定量分析[J]. 中国医疗设备, 2016, 31(12): 10-16.
LIN Lan, ZHANG Bai-wen,
WU Shui-cai. Quantitative Analysis of Cognitive Reserve of the Healthy Elder Brain
Based on BrainAGE. China Medical Devices, 2016, 31(12): 10-16.