Protective Effect of Multimodal Navigation and Intraoperative Magnetic Resonance
Imaging on Language Function in Cerebral Lesions Involving Language Area
LI Fangye, CHEN Xiaolei, HOU Yuanzheng, SUN Guochen, ZHANG Jiashu, YU Xinguang, XU Bainan
Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China
Abstract：Objective To evaluate the impact of multimodal navigation and intraoperative magnetic resonance imaging (iMRI)
on extent of resection, gross total resection and preservation of language function. Methods A total of 65 patients with cerebral
lesions involving arcuate fasciculus (AF) were enrolled. Impact of multimodal navigation and iMRI on surgical strategies, extent of
resection, rate of gross total resection (GTR) and language function were analyzed. Results Extent of resection was overestimated
in 12 cases (18.5%) by the neurosurgeons, compared with the first iMRI. The first iMRI confirmed total resection of non-glioma
lesions. First iMRI demonstrated gross total resection in 21 patients and incomplete resection in 33 cases. Further resection was
continued with updated imaging in 25 patients. Additional tumor resection in 25 cases increased extent of resection from 87.3%
to 97.4%, resulting in improvement of mean resection degree in glioma cases from 92.1% to 96.8%. Compared with preoperative
language function status, 15 cases (23.1%) got new or worsened language dysfunction 2 weeks after surgery. At 6-month followup,
only 2 patients had a permanent postoperative language deficit. Conclusion Multimodal navigation and iMRI help maximal
resection of cerebral lesions while minimum injury to language function, which can improve health related quality of life.
李昉晔，陈晓雷，侯远征，孙国臣，张家墅，余新光，许百男. 功能神经导航及术中磁共振对语言区病变语言保护作用研究[J]. 中国医疗设备, 2017, 32(12): 11-14.
LI Fangye, CHEN Xiaolei, HOU Yuanzheng, SUN Guochen, ZHANG Jiashu, YU Xinguang, XU Bainan. Protective Effect of Multimodal Navigation and Intraoperative Magnetic Resonance
Imaging on Language Function in Cerebral Lesions Involving Language Area. China Medical Devices, 2017, 32(12): 11-14.
