基于磁吻合技术的经自然腔道胃结肠吻合实验研究

doi:11.3969/j.issn.1674-1633.2020.11.017

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摘要目的探讨利用磁吻合技术经自然腔道实现无创化胃结肠吻合的可行性。方法以SD大鼠为动物模型，设计并加工适用于大鼠的可经口和经肛置入的吻合磁体。大鼠麻醉后经口置入子磁体至胃内，经肛置入母磁体于结肠脾曲，子母磁体自动对位吸合。腹部X线明确磁体吸合状态及位置，记录磁体排出时间。1个月后获取吻合口标本，肉眼观察吻合口形成情况。结果8只SD大鼠成功实施了经口经肛途径的无创化胃结肠磁吻合，术中磁体置入过程顺利，X线监测下可见子母磁体自动对位吸合良好。术后12~17d磁体随粪便经肛门排出。术后1个月处死动物，获取胃结肠吻合口标本，肉眼观察可见胃肠吻合口通畅性良好，吻合口爆破压(114!10.25)mmHg。结论利用磁吻合技术，通过自然腔道途径可实现无创化胃结肠吻合。

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关键词 ：磁吻合, 胃肠吻合, 磁压榨技术, 磁外科, 经自然腔道

Abstract：Objective To explore the feasibility of non-invasive gastrointestinal anastomosis by using magnamosis technique through natural orifice transluminal endoscopic surgery. Methods SD rats were used as animal models to design and process anastomotic magnets that could be inserted through the oral and anus. After anesthesia, the daughter magnet was implanted into the stomach through the mouth and the parent magnet was implanted into the splenic flexure of colon through the anus, then the daughter and parent magnets were automatically attached to each other. The state and position of magnet suction were confirmed by abdominal X-ray, and the discharge time of magnet were recorded. The anastomotic specimens were obtained after 1 month, and the formation of anastomotic was observed visually. Results The non-invasive gastrointestinal magnamosis was successfully carried out in eight SD rats through the oral and anal pathway. The process of magnet placement was smooth during the operation, and the X-ray monitoring showed that the magnets was automatically aligned and attached. The magnets were excreted through the anus 12-17 days after operation. One month after operation, the animals were killed and the gastrointestinal anastomotic specimens were obtained. Macroscopic observation showed that the gastrointestinal anastomotic patency was good, and the burst pressure of anastomotic was 114 ±10.25 mmHg. Conclusion Non-invasive gastrointestinal anastomosis can be achieved by using magnamosis technique through natural orifice transluminal endoscopic surgery.

Key words： magnamosis gastrointestinal anastomosis magnetic compression technique magnetic surgery natural orifice transluminal endoscopic surgery

收稿日期: 2020-10-27

ZTFLH:

R656

基金资助:国家自然科学基金（81700545）|陕西省自然科学基础研究计划（2017JQ8021）| 中央高校基本科研业务费专项资金（xjj2018jchz14）| 西安交通大学大学生创新训练项目（SJ201910698194）。

通讯作者: 严小鹏 E-mail: yanxiaopeng99@166.com

引用本文:

严小鹏^1a,1b，张苗苗^1a,1b，吉琳^1a,1b,2a，张涵芷^1a,1b,2a，李恒^1a,1b,2a，牟星宜^1a,1b,2b，徐庶钦^1a,1b,2b，雷凤萍^1a,1b,2a，马佳³，吕毅^1a,1b. 基于磁吻合技术的经自然腔道胃结肠吻合实验研究[J]. 中国医疗设备, 2020, 35(11): 58-60.
YAN Xiaopeng^1a,1b，ZHANG Miaomiao^1a,1b，JI Lin^1a,1b,2a，ZHANG Hanzhi^1a,1b,2a，LI Heng^1a,1b,2a，MOU Xingyi^1a,1b,2b，XU Shu qin^1a,1b,2b，LEI Fengping^1a,1b,2a，MA Jia³，LV Yi^1a,1b. Experimental Study on Gastrointestinal Anastomosis Through Natural Orifice Transluminal Endoscopic Surgery Based on Magnamosis Technique. China Medical Devices, 2020, 35(11): 58-60.

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http://cs.china-cmd.org/zgylsb/CN/11.3969/j.issn.1674-1633.2020.11.017 或 http://cs.china-cmd.org/zgylsb/CN/Y2020/V35/I11/58

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