磁环构建大鼠胆肠吻合模型的实验研究

doi:11.3969/j.issn.1674-1633.2020.11.014

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (2315 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨磁环构建大鼠胆肠吻合模型的可行性。方法设计并加工适用于大鼠胆肠吻合模型的磁环。10只雄性SD大鼠结扎胆总管，2周后胆总管扩张。利用磁环完成胆总管十二指肠吻合操作。记录吻合时间、术后存活率及并发症发生情况。28d 后获取吻合口标本，肉眼观察胆肠吻合口愈合情况。结果10只SD大鼠中，1只大鼠胆总管结扎后1周出现胆漏并死亡，1只因胆总管未见明显扩张而剔除实验，其余8只大鼠利用磁环顺利完成胆肠吻合手术操作，平均吻合时间(5.22!1.83)min。术后28d 获取胆肠吻合口标本，肉眼观察可见吻合口黏膜层连续性良好，吻合口通畅。结论磁环可用于构建大鼠胆肠吻合模型，且具有操作简单、吻合效果可靠等优点。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	吉琳^1b
	1b
	2a
	常凯曦^1b
	2
	王俊翔^1b
	2
	李一鹤^1b
	2
	王伊睿^1b
	2
	吕毅^1a
	1b
	严小鹏^1a
	1b

关键词 ：磁吻合, 大鼠, 胆肠吻合, 动物模型, 磁外科

Abstract：Objective To explore the feasibility of establishing bilioenteric anastomosis by magnetic ring in rat model. Methods A new magnamosis ring suitable for rat bilioenteric anastomosis model was designed and fabricated. 10 male Sprague-Dawley albino rats were ligated with common bile duct and dilated after 2 weeks. The operation of bilioenteric anastomosis was completed by magnetic ring. The anastomosis time, postoperative survival rate and complications were recorded. After 28 days, anastomotic specimens were obtained to observe healing with the naked eye. Results Among the 10 Sprague-Dawley albino rats, 1 rat died of bile leakage 1 week after ligation of common bile duct. 1 was removed from the experiment because there was no obvious dilatation of the common bile duct. The remaining 8 rats successfully completed the operation of bilioenteric anastomosis with magnetic ring, with an average anastomosis time of (5.22±1.83) min. The bilioenteric anastomosis specimens were obtained 28 days after the operation, and macroscopic observation showed that the mucosal layer of the anastomosis had good continuity and the anastomosis was smooth. Conclusion Magnetic ring can be used to construct rat bilioenteric anastomosis model which has the advantages of simple operation and reliable anastomosis effect.

Key words： magnamosis rats bilioenteric anastomosis animal model magnetic surgery

收稿日期: 2020-05-28

ZTFLH:

R656

基金资助:国家自然科学基金（81700545）|陕西省自然科学基础研究计划（2017JQ8021）|中央高校基本科研业务费专项资金（xjj2018jchz14）|西安交通大学大学生创新训练项目（GJ202010698122）。。

通讯作者: 严小鹏 E-mail: yanxiaopeng99@163.com

引用本文:

吉琳^1b,1b,2a，常凯曦^1b,2，王俊翔^1b,2，李一鹤^1b,2，王伊睿^1b,2，吕毅^1a,1b，严小鹏^1a,1b. 磁环构建大鼠胆肠吻合模型的实验研究[J]. 中国医疗设备, 2020, 35(11): 49-51.
JI Lin^1b,1b,2a，CHANG Kaixi^1b,2，WANG Junxiang^1b,2，LI Yihe^1b,2，WANG Yirui^1b,2，LV Yi^1a,1b，YAN Xiaopeng^1a,1b. An Experimental Study of Bilioenteric Anastomosis Construction by Magnetic Ring in Rat Model. China Medical Devices, 2020, 35(11): 49-51.

链接本文:

http://cs.china-cmd.org/zgylsb/CN/11.3969/j.issn.1674-1633.2020.11.014 或 http://cs.china-cmd.org/zgylsb/CN/Y2020/V35/I11/49

[1]	马锋^a,b，丁泓帆^a,b,c，刘学民^a,b,c，严小鹏^a,b,c，李宇^a,b,c，张谞丰^a,b,c，张晓刚^a,b,c，白纪刚^a,b,c，王博^a,b,c，仵正^a,b,c，吴荣谦^a,b，吕毅^a,b,c. 基于磁力压迫技术的高位胆肠吻合装置的设计[J]. 中国医疗设备, 2020, 35(8): 5-7.
[2]	史爱华^a,b，卢强^a,b,c，严小鹏^a,b,c，王善佩^a,b,c，刘康^a,b,c，马锋^a,b，乔玮a,b,c，王浩华^a,b，吕毅^a,b,c. 磁辅助快速肝移植的血管吻合装置的设计[J]. 中国医疗设备, 2020, 35(8): 8-10.
[3]	单丽宇^a,b，张楠^a,b，马锋^a,b，吕毅^a,b,c，贺海奇^a,b,d. 磁悬浮技术在医疗器械研发方面的应用进展[J]. 中国医疗设备, 2020, 35(8): 11-15.
[4]	康诗然^1a,1b,2a，刘博^1b,2b，武佳宜^1b,2b，加伟^1b,2b，马佳^1b,3，张勇^1b,1c，马锋^1b，吕毅^1a,1b，严小鹏^1a,1b. 磁锚定设备辅助减戳孔腹腔镜子宫切除的实验研究[J]. 中国医疗设备, 2020, 35(5): 56-58.
[5]	严小鹏^1a,1b，张苗苗^1a,1b，张涵芷^1b,2a，李益行^1b,2a，陈诗^1b,2b，郭晨东^1b,2a，刘培楠^1b,2a，史爱华^1b，吕毅^1a,1b. 用于内镜下胃肠旁路吻合的可变形自组装磁吻合环的设计[J]. 中国医疗设备, 2020, 35(11): 42-44.
[6]	张苗苗^1a,1b，吉琳^1a,1b,2a，牟星宜^1a,1b,2b，张涵芷^1a,1b,2a，李益行^1a,1b,2a，畅朋康^1a,1b，吕毅^1a,1b，严小鹏^1a,1b. 磁吻合研究现状与发展趋势[J]. 中国医疗设备, 2020, 35(11): 45-48.
[7]	叶丹^1a,1b,2a，陈雯雯^2a，高慧敏^2a，张家辉^2b，沈玮晨^2a，史爱华^1b，马锋^1b，张勇^1b,1c，吕毅^1a,1b，严小鹏^1a,1b. 食管胃磁吻合动物实验研究[J]. 中国医疗设备, 2020, 35(11): 52-54.
[8]	张曼^a，张苗苗^a,b，田波彦^a，白纪刚^a,b，吕毅^a,b，严小鹏^a,b. 磁锚定腹腔镜胆囊切除围手术期护理[J]. 中国医疗设备, 2020, 35(11): 55-57.
[9]	严小鹏^1a,1b，张苗苗^1a,1b，吉琳^1a,1b,2a，张涵芷^1a,1b,2a，李恒^1a,1b,2a，牟星宜^1a,1b,2b，徐庶钦^1a,1b,2b，雷凤萍^1a,1b,2a，马佳³，吕毅^1a,1b. 基于磁吻合技术的经自然腔道胃结肠吻合实验研究[J]. 中国医疗设备, 2020, 35(11): 58-60.
[10]	马佳^1,2a，祝旭龙^1,2a，李建辉^1,2a，程冲^1,2a，章建飞^1,2a，吕毅^2a,2b，严小鹏^2a,2b. 磁力可调式消化道磁吻合装置的研制[J]. 中国医疗设备, 2019, 34(3): 9-11.
[11]	邱明龙 ^1a,1b,2a，高慧敏^1b,2a，叶丹 ^1b,2a，袁宗玲 ^1b,2a，刘豪^1a,1b,2a，付珊^1a,1b,2a，雷蕾 ^1b,2a，邓博^1b,2b，单丽宇^1a,1b,2b，史爱华^1b，吕毅^1a,1b，严小鹏^1a,1b. 磁体差异性结构设计在磁压榨技术中的应用分析[J]. 中国医疗设备, 2019, 34(3): 1-4.
[12]	单丽宇^1a,1b,2a，雷蕾^1b,2b，邓博^1b,2a，叶丹^1b,2b，李益行^1b,2b，杨毓锐^1b,2b，袁宗玲^1b,2b，郝苗^1b,2b，吴剑华^1b,2b，吕毅^1a,1b，严小鹏^1a,1b. 基于磁压榨技术的先天性肛门闭锁再通吻合装置的设计[J]. 中国医疗设备, 2019, 34(3): 12-14.
[13]	马思捷^1a,1b,2a，杜妍莹^1a,1b，赵广宾^2b，马锋^1b，史宗谦^2c，王立军^2c，孙昊^1a,1b，白纪刚^1a,1b，莫永鹏^2c，李宇^1a,1b，吴荣谦^1b，吕毅^1a,1b，严小鹏^1a,1b. 磁锚定技术辅助内镜下胃空肠吻合[J]. 中国医疗设备, 2019, 34(3): 15-18.
[14]	刘豪^1a,1b,2a，赵广宾^2b，张勇^1b,1c，韩珍珍^1b，史爱华^1b，吕毅^1a,1b，严小鹏^1a,1b. 基于磁锚定技术的磁性水凝胶辅助内镜黏膜下剥离术[J]. 中国医疗设备, 2019, 34(3): 19-21.
[15]	田波彦¹，马佳²，刘豪³，付珊³，吕毅^1,4，严小鹏^1,4. 磁控腹腔镜手术内置抓钳离合系统的设计[J]. 中国医疗设备, 2018, 33(8): 70-73.