Preliminary Study on the Relationship Between the Parameters of Contrast-Enhanced
Ultrasound and VEGF & TGF-β1 in Benign and Malignant Lesions of Prostate
LIU Qian, HONG Hua, YANG Jingchun, WANG fang, LI Min, SUN Ran, WU Guozhu
Department of Ultrasound, Inner Mongolia People’s Hospital, Hohhot Inner Mongolia 010017, China
Abstract：Objective To study the correlation between the contrast-enhanced ultrasound parameters of benign and malignant prostate
lesions and the level of serum VEGF, TGF-β1. Methods Serum VEGF and TGF-1 were measured by enzyme-labeled immunosorbent
assay in 118 patients with suspected prostate cancer. Transrectal prostate contrast-enhanced ultrasonography and transrectal prostate
biopsy guided by color ultrasound were performed. The time-intensity curve of the lesion was analyzed by quantitative analysis
software, and the quantitative parameters were obtained by fitting the curve. According to the pathological results of puncture, the
patients were divided into benign prostate lesions group and malignant prostate lesions group, and the contrast-enhanced ultrasound
parameters, serum VEGF value and TGF- 1 value of the two groups were compared, and the correlation between the contrast-enhanced
ultrasound parameters, serum VEGF value and TGF-1 value were analyzed. Results Among the 118 patients, 112 were included
in the study, including 60 cases of benign prostatic hyperplasia and 52 cases of prostate cancer. There were six parameters including
RT, PI, MTT, AUC, WIS and TTP in benign lesions and malignant lesions were significantly different (P<0.01). The serum levels of
VEGF and TGF-β1 in benign lesions and malignant lesions were significantly different (P<0.01). There was a significant and positive
correlation between the contrast-enhanced ultrasound parameter PI and the level of serum VEGF; WIS was positively correlated with
the level of serum VEGF; TTP was negatively correlated with the level of serum VEGF. The contrast-enhanced ultrasound parameter
RT was negatively correlated with the level of serum TGF-β1; PI was significantly and positively correlated with the level of serum
TGF-β1; AUC was positively correlated with the level of serum TGF-β1; WIS was positively correlated with the level of serum
TGF-β1. Conclusion The contrast-enhanced ultrasound parameters can reflect the angiogenesis of prostate cancer and can be used
to guide the targeted transrectal prostate biopsy. Serum VEGF value and TGF- 1 value can reflect the biological behavior of prostate
cancer and have certain value in the treatment and efficacy evaluation of prostate cancer.
刘倩，红华，杨敬春，王芳，李敏，孙冉，吴国柱. 前列腺良恶性病变超声造影参数与VEGF、TGF-β1相关性的初步研究[J]. 中国医疗设备, 2019, 34(4): 95-99.
LIU Qian, HONG Hua, YANG Jingchun, WANG fang, LI Min, SUN Ran, WU Guozhu. Preliminary Study on the Relationship Between the Parameters of Contrast-Enhanced
Ultrasound and VEGF & TGF-β1 in Benign and Malignant Lesions of Prostate. China Medical Devices, 2019, 34(4): 95-99.
