Study on Au Nanoparticles for Photoacoustic Imaging of Mice Breast Cancer
ZU Lihui1, DAI Yimeng1, HU Zhenzhen1, HAN Liang2, LIU Jingxin1
1. Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun Jilin 130021, China;
2. Department of Pathology, China-Japan Union Hospital, Jilin University, Changchun Jilin 130021, China
Abstract：Objective To construct gold nanoparticles for photoacoustic imaging (PA) and explore the characteristics of PA imaging.
Methods Bovine serum albumin-capped Au nanoparticles were synthesized from bovine serum albumin. Au nanoparticles were
characterized by various methods. PA imaging of 4T1 breast cancer was performed at different time points after intravenous
administration. Results The nanoparticles were in star-like structure and uniform size. The nanoparticles had an average diameter
of 85 nm and the surface plasmon resonance (SPR) peak was at 770 nm. MTT test and pathological results showed no obvious
biological toxicity. PA imaging results showed that the tumor tissue was significantly enhanced after administration. Conclusion The
Au nanoparticles exhibites good biocompatibility and excellent photoacoustic imaging effects of tumor.
祖莅惠1，代一猛1，胡真真1，韩亮2，刘景鑫1. 金纳米粒子用于小鼠乳腺癌光声成像研究[J]. 中国医疗设备, 2019, 34(4): 33-37.
ZU Lihui1, DAI Yimeng1, HU Zhenzhen1, HAN Liang2, LIU Jingxin1. Study on Au Nanoparticles for Photoacoustic Imaging of Mice Breast Cancer. China Medical Devices, 2019, 34(4): 33-37.
