Application of Stereotactic Radiotherapy in Recurrent Glioma
SHEN Ge1, KANG Jing-bo2
1.Department of Radiotherapy, The 307th Hospital of PLA, Beijing 100071, China; 2.Department of Radiotherapy, Navy General Hospital, Beijing 100037, China
Abstract：Objective To review the application progress of stereotactic radiotherapy in recurrent glioma of recent years. Methods After listing out the types of recurrent glioma, this paper introduced the exposure dose, extent and effect of stereotactic radiotherapy in the treatment of recurrent glioma, and finally compared the curative effect that of combining it with drugs. Results The recurrence of glioma mainly occurred in the first-time radiation field. Stereotactic radiotherapy should be applied in the re-irradiation of recurrent gliomas and the application can be single-time, multiple-times or combined with temozolomide and bevacizumab, which can significantly improve the curative effect. Conclusion The stereotactic radiotherapy is highly effective in the treatment of recurrent gliomas, but more studies of exposure dose, extent and combination with drugs should be conducted.
申戈，康静波. 立体定向放疗在复发胶质瘤中的应用[J]. 中国医疗设备, 2014, 29(10): 9-11.
SHEN Ge, KANG Jing-bo. Application of Stereotactic Radiotherapy in Recurrent Glioma. China Medical Devices, 2014, 29(10): 9-11.
Norden AD,Young GS,Setayesh K,et al.Bevacizumab for recurrent malignant gliomas:efficacy,toxicity,and patterns of recurrence[J].Neurology,2008,70:779-787.
[2]
Oermann E,Collins BT,Erickson KT,et al.CyberKnife enhanced conventionally fractionated chemoradiation for high grade glioma in close proximity to critical structures[J].J Hematol Oncol,2010,3:22.
[6]
Pope WB,Xia Q,Paton VE,et al.Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab[J]. Neurology,2011,76:432-437.
[3]
Brandes AA,Tosoni A,Franceschi E,et al.Recurrence pattern after temozolomide concomitant with and adjuvant to radiotherapy in newly diagnosed patients with glioblastoma:correlation with MGMT promoter methylation status[J].J Clin Oncol,2009,27:1275-1279.
[9]
Shapiro LQ,Beal K,Goenka A,et al.Patterns of failure after concurrent bevacizumab and hypofractionated stereotactic radiation therapy for recurrent high-grade glioma[J].Int J Radiat Oncol Biol Phys,2013,85(3):636-642.
[20]
Thumma SR,Elaimy AL,Daines N,et al.Long-term survival after gamma knife radiosurgery in a case of recurrent glioblastoma multiforme:a case report and review of the literature[J].Case Rep Med,2012,4:545492.
[21]
Shaw E,Scott C,Souhami L,et al.Radiosurgery for the treatment of previously irradiated recurrent primary brain tumors and brain metastases:initial report of radiation therapy oncology group protocol (90-05) [J].Int J Radiat Oncol Biol Phys,1996,34(3):647-654.
[22]
Koga T,Maruyama K,Tanaka M,et al.Extended field stereotactic radiosurgery for recurrent glioblastoma[J].Cancer,2012,118(17):4193-4200.
[1]
Stupp R,Hegi ME,Mason WP,et al.Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study:5-year analysis of the EORTCNCIC trial[J].Lancet Oncol,2009,10:459-466.
[4]
Milano MT,Okunieff P,Donatello RS,et al.Patterns and timing of recurrence after temozolomide-based chemoradiation for glioblastoma[J].Int J Radiat Oncol Biol Phys,2010,78:1147-1155.
[8]
Chamberlain MC.Radiographic patterns of relapse in glioblastoma[J]. J Neurooncol,2011,101:319-323.
[11]
Cuneo KC,Vredenburgh JJ,Sampson JH,et al.Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas[J].Int J Radiat Oncol Biol Phys,2012, 82(5):2018-2024.
[5]
McDonald MW,Shu HK,Curran WJ Jr,et al.Pattern of failure after limited margin radiotherapy and temozolomide for glioblastoma[J].Int J Radiat Oncol Biol Phys,2011,79:130-136.
[10]
Hallemeier CL,Pollock BE,Schomberg PJ,et al.Stereotactic radiosurgery for recurrent or unresectable pilocytic astrocytoma[J].Int J Radiat Oncol Biol Phys,2012,83(1):107-112.
[12]
Park KJ,Kano H,Iyer A,et al.Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme:a case-control study[J].J Neurooncol,2012, 107(2):323-333.
[13]
Conti A,Pontoriero A,Arpa D,et al.Efficacy and toxicity of CyberKnife re-irradiation and "dose dense" temozolomide for recurrent gliomas[J].Acta Neurochirurgica,2012,154(2):203-209.
[14]
Combs SE,Bischof M,Welzel T,et al.Radiochemotherapy with temozolomide as re-irradiation using high precision fractionated stereotactic radiotherapy (FSRT) in patients with recurrent gliomas[J].J Neurooncol,2008,89(2):205-210.
[15]
Minniti G,Armosini V,Salvati M,et al.Fractionated stereotactic reirradiation and concurrent temozolomide in patients with recurrent glioblastoma[J].J Neurooncol,2011,103(3):683-691.
[16]
Minniti G,Scaringi C,De Sanctis V,et al.Hypofractionated stereotactic radiotherapy and continuous low-dose temozolomide in patients with recurrent or progressive malignant gliomas[J]. J Neurooncol,2013,111(2):187-194.
[17]
Gutin PH,Iwamoto FM,Beal K,et al.Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas[J].Int J Radiat Oncol Biol Phys, 2009,75(1):156-163.
[18]
Cabrera AR,Cuneo KC,Desjardins A,et al.Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas:a prospective trial[J].Int J Radiat Oncol Biol Phys,2013,86(5):873-879.
[19]
Larson EW,Peterson HE,Lamoreaux WT,et al.Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma[J].World J Clin Oncol,2014,5(2):142-148.
