热波动分析是近年来发展的一类皮肤微循环功能障碍检测方法，目前相关的软、硬件的发展还处于比较早期的阶 段，距临床应用还有较大距离。为便于使用小波分析方法对微循环血流/温度信号进行时频分析，本文基于MATLAB GUI编 程开发了一个有图像用户界面的应用软件，该软件主要包括了文件模块、小波分析模块、检测结果模块以及相关性分析模 块4部分。本文首先介绍了小波分析方法在生物信号分析中的应用，然后通过几个实例对软件的信号小波变换、信号波动 幅值变化提取、检测结果统计以及信号互相关分析功能进行了介绍，期望本软件能够在血流/温度信号时频分析、微循环功 能检测方面提供帮助。

Thermal wave analysis is an indirect method for the detection of skin microcirculation dysfunction developed in recent years. However, the development of related hardwares and softwares are still in the early stages and can’t satisfy the needs of clinical applications very well. In order to easily perform the time-frequency analysis of microvascular blood flow and temperature signals by using wavelets, we developed an application software with graphical user interface based on MATLAB GUI, including four modules: files, wavelet analysis, detection results and correlation analysis. We firstly introduced the application of wavelets in the analysis of biological signals. The function of this software was introduced briefly with some real cases, such as: signal wavelet transforms, the extraction of signal fluctuation amplitude, statistics of detection results and signal cross-correlation analysis. It is expected that the software we described in this paper can aid the time-frequency analysis of biological signals and the detection of skin microcirculation dysfunctions.