Clinical Application of Intelligent Radiographic Absorptiometry–Human Forearm’s
Bone Mineral Measurements and the Osteoporosis Assessments
CHEN Jianfeng1, FAN Yunzhou2, LI Peng2, HUANG Songzheng2
1.Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago Illinois 60611, USA; 2.Department of
Research and Development, Zhejiang Kangyuan Medical Devices Incorporation, Hangzhou Zhejiang 310051, China
Abstract：Objective In this paper, a bone mineral measurement method called intelligent radiographic absorptiometry (i-RA) was
described and the measurement results were presented. Methods Firstly, digital radiography (DR) images were acquired from 228
human volunteers’ forearms in vivo, then the i-RA method was used to process these DR images, the algorithm automatically placed
the region of interest on the radius centered at 1/3 of the non-dominant forearm length measured from the styloid process on the
ulna, both values of the bone mineral density (BMD) and T-score of these regions were determined. Results By comparing with the
measurement results with using dual-energy X-ray absorptiometry (DXA), which had been widely used for BMD measurements and
was defined as World Health Organization gold standard, the measurement results showed that the Pearson’s correlation coefficients
were 0.984 for BMD, and 0.979 for T-scores, and the ROC results showed that sensitivity was 98.5%, specificity was 98.2%, area
under curve was 0.998. Conclusion DXA method can be potentially replaced by the i-RA method to measure human radius’ BMD
and T-scores, and to diagnose osteoporosis.
陈建锋1，范运洲2，李鹏2，黄松正2. 智能放射吸收法的临床应用——人体手臂骨骨密度的测量及其骨质疏松的评估[J]. 中国医疗设备, 2018, 33(3): 31-35.
CHEN Jianfeng1, FAN Yunzhou2, LI Peng2, HUANG Songzheng2. Clinical Application of Intelligent Radiographic Absorptiometry–Human Forearm’s
Bone Mineral Measurements and the Osteoporosis Assessments. China Medical Devices, 2018, 33(3): 31-35.
