Abstract：Objective To explore the effectiveness of application of the spectral CT for the treatment of
endostatin of the rabbit VX2 liver cancer model. Methods The 68 rabbits with VX2 liver tumors were
randomly and evenly divided into Control Group and Trial Group with 34 rabbits in either group. From the 14
d after tumor transplantation, Group A was injected with endostain at the dose of 0.3 mg/kg continuously for
7 d; while, Group B was injected with saline and endostain at the same dose of 0.3 mg/kg with Group A
continuously for 7 d, The rabbits were scanned to obtain gemstone spectral images. The reconstructed
image data were transmitted to the image processing workstation for analysis. The iodine content of
the tumor, area without tumor and the abdominal aorta were measured in the iodine map to calculate
NIC (Normalized Iodine Concentrations). And the pre- and post-treatment NIC was compared. Results
The NIC of the tumor tissue in both Group A and Group B were higher than the liver tissue without
tumor, with statistically significant difference (P<0.05). After the endostatin Endostar treatment, the
NIC of tumor of Trail Group was less than that of Control Group, and less than pre-trestment NIC, with
statistically significant (P<0.05). Conclusion The endostain Endosar showed obvious antiangiogenic
effects in spectrum CT scan to evaluate the tumor angiogenesis and the effect of the anti-angiogenesis
therapy.
王明月，周悦，董军强，高剑波. 能谱CT评价兔VX2肝癌抗血管生成治疗的实验研究[J]. 中国医疗设备, 2016, 31(7): 19-21.
WANG Ming-yue, ZHOU Yue,
DONG Jun-qiang, GAO Jian-bo. Experimental Study on the Evaluation of Anti-Angiogenesis Therapy
in Rabbit VX2 Liver Cancers by Spectrum CT. China Medical Devices, 2016, 31(7): 19-21.
