Research on Skin Safety of UVC Light with 275 nm Wavelength
SONG Chenghua1a,1b, YANG Xiya1a,1b, SHI Aihua1a,1b, WEI Jiali1a,1b, LI Yufeng2,3, LV Yi1a,1b, WU Rongqian1a,1b
1. a. Shaanxi Province Center for Regenerative Medicine and Surgery Engineering Research; b. National Local Joint Engineering
Research Center for Precision Surgery & Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an
Shaanxi 710061, China; 2. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou Zhejiang 325001, China;
3. Shaanxi Key Laboratory of Photonics Technology for Information, Xi’an Jiaotong University, Xi’an Shannxi 710049, China
Abstract：Objective To explore the effects of 275 nm ultraviolet C (UVC) light irradiation on the survival and growth of skin cells
and vascular endothelial cells, as well as the effects of long-term and short-term irradiation on the skin of nude mice, and to identify
its safety. Methods Human immortalized keratinocytes cells and human umbilical vein endothelial cells were irradiated with 275 nm
UVC-LED light source developed, designed and processed by the laboratory for different durations to observe the effects of different
irradiation dosages on the survival and growth of the cells; the nude mice skin was irradiated for different durations to observe
changes in the appearance of the skin, and tissues of irradiated areas were collected for immunohistochemical analysis. Results For
low doses of direct irradiation of cells, 275 nm UVC light had certain skin-related cell safety. However, the high dose of 275 nm
UVC light irradiation caused more damage to the cells. Meanwhile, neither low-dose nor high-dose irradiation of 275 nm UVC light
induced DNA and epidermal damage in nude mice skin. Conclusion The 275 nm UVC light has been identified as promising for
clinical applications, and is relatively safe for the skin.
宋承华1a,1b，杨晰雅1a,1b，史爱华1a,1b，魏嘉丽1a,1b，李虞锋2,3，吕毅1a,1b，吴荣谦1a,1b. 275 nm波长UVC光的皮肤安全性研究[J]. 中国医疗设备, 2024, 39(2): 16-21.
SONG Chenghua1a,1b, YANG Xiya1a,1b, SHI Aihua1a,1b, WEI Jiali1a,1b, LI Yufeng2,3, LV Yi1a,1b, WU Rongqian1a,1b. Research on Skin Safety of UVC Light with 275 nm Wavelength. China Medical Devices, 2024, 39(2): 16-21.
