目的 探讨外周血热休克蛋白90α（Heat Shock Protein 90α，HSP90α）、脊髓趋化因子CXC配体12（Spinal Cord Chemokine CXC Ligand 12，CXCL12）联合检测对肺癌的诊断价值。方法 将2016年1月至2019年6月我院收治的232例原发 性肺癌患者作为研究对象，并选择168名健康体检者作为健康对照组，比较两组外周血HSP90α、CXCL12表达水平，采用 受试者工作特征（Receiver Operating Characteristic，ROC）曲线分析患者HSP90α、CXCL12表达水平对肺癌的诊断价值。 结果 肺癌患者外周血HSP90α、CXCL12表达水平显著高于健康对照组，差异具有统计学意义（P<0.001）。HSP90α 以121.41 ng/mL为诊断截断值时，诊断肺癌的敏感度为73.28%，特异度为76.19%，ROC曲线下面积（Area Under Curve， AUC）为0.746（95%CI：0.691~0.802）；CXCL12以458.41 pg/mL为诊断截断值时，诊断肺癌的敏感度为70.69%，特异 度为77.98%，AUC为0.681（95%CI：0.616~0747）；外周血HSP90α、CXCL12联合检测的敏感度（85.34%）显著高于单 项检测的敏感度，AUC为0.867（95%CI：0.829~0.906），显著高于各单项检测，诊断效能最佳。结论 肺癌患者外周血 HSP90α、CXCL12呈显著高表达，两者联合检查可提高诊断效能，对于原发性肺癌患者诊断具有潜在应用价值。

Objective To investigate the diagnostic value of combined detection of peripheral blood heat shock protein 90α (HSP90α) and spinal cord chemokine CXC ligand 12 (CXCL12) for lung cancer. Methods A total of 232 primary lung cancer patients admitted to our hospital from January 2016 to June 2019 were selected as the research subjects, and 168 healthy subjects were selected as the healthy control group. The expression levels of HSP90α and CXCL12 in the peripheral blood between the two groups were compared. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of the expression levels of HSP90α and CXCL12 in patients with lung cancer. Results The expression levels of HSP90α and CXCL12 in peripheral blood of patients with lung cancer were significantly higher than those of healthy control group, and the differences were statistically significant (P<0.001). When the cut-off value of HSP90α was 121.41 ng/mL, the sensitivity for diagnosing lung cancer was 73.28%, the specificity was 76.19%%, and the area under the ROC curve (AUC) was 0.746 (95%CI: 0.691-0.802). When the cut-off value of CXCL12 was 458.41 pg/mL, the sensitivity for the diagnosis of lung cancer was 70.69%, the specificity was 77.98%, and the AUC was 0.681 (95%CI: 0.616-0747). The sensitivity of combined detection of HSP90α and CXCL12 in peripheral blood (85.34%) was significantly higher than that of single detection, and the AUC was 0.867 (95%CI: 0.829-0.906), which was significantly higher than that of single detection, and the diagnostic efficiency was the best. Conclusion Peripheral blood HSP90α and CXCL12 are significantly high in patients with lung cancer. The combined examination of HSP90α and CXCL12 can improve the diagnostic efficiency, which has potential application value in the diagnosis of patients with primary lung cancer.