Abstract：Objective To study the value of low-dose and high-dose dual-source CT perfusion imaging (CTP) in diagnosing
hyperacute cerebral infarction. Methods A total of 74 patients with hyperacute cerebral infarction admitted to our hospital from
November 2020 to January 2022 were selected as the research subjects, and they were divided into high-dose group and low-dose
group by random number table method. All patients received dual-source CTP within 6 hours of onset, and the tube current of the
high-dose group was 120 mA, and the tube current of the low-dose group was 80 mA.The time to maximum (Tmax), cerebral blood
flow (CBF), cerebral blood volume (CBV) and time to peak (time to peak, TTP), time to drain (TTD) and other parameters of pseudo
color map were obtained. Magnetic resonance imaging (MRI) diffusion weighted imaging (DWI) was used as the gold standard for
the diagnosis of hyperacute cerebral infarction. The consistency between high-dose and low-dose dual-source CTP in the diagnosis of
hyperacute cerebral infarction and the gold standard was analyzed. Results The results of dual-source CTP examination showed that
in the low-dose group and the high-dose group, there were 7 and 8 cases of semi-oval central cerebral infarction, 20 and 19 cases of
brainstem infarction, and 10 cases of paraventricular cerebral infarction, respectively. The sensitivity of diagnosis of semi-oval central
cerebral infarction was 0.857 and 0.857, the specificity was 0.967 and 0.933, the accuracy was 0.946 and 919, and the Kappa value
was 0.824 and 0.749, respectively. The sensitivity of diagnosing brainstem infarction was 0.944 and 0.889, the specificity was 0.842
and 0.842, the accuracy was 0.892 and 0.865, and the Kappa value was 0.784 and 0.730, respectively. The sensitivity, specificity,
accuracy and Kappa value in the diagnosis of paraventricular cerebral infarction were 0.833 and 0.833, 0.982 and 0.960, 0.946 and
0.919, 0.871 and 0.810, respectively. There was no significant difference between the two groups in diagnostic efficacy (P>0.05).
Compared with the high-dose group, the effective radiation dose of the low-dose group was decreased by 30.62% (0.64/2.09), and
the difference was statistically significant (P<0.05). Conclusion The diagnostic results of high-dose and low-dose dual-source CTP
in hyperacute cerebral infarction were highly consistent with those of DWI. Low-dose dual-source CTP was beneficial to reduce the
effective radiation dose and meet the diagnostic requirements.
骆栋梁，张维春. 双源CT低剂量与高剂量CTP在超急性期脑梗死诊断中的应用价值[J]. 中国医疗设备, 2022, 37(11): 103-106.
LUO Dongliang, ZHANG Weichun. Application Value of Low-dose and High-dose Dual Source CTP for Hyperacute Cerebral Infarction. China Medical Devices, 2022, 37(11): 103-106.
