Abstract：Objective To discuss the effectiveness of cellblock paraffin-imbedded sections in diagnosis of malignant serous cavity effusion. Methods A total of 560 patients were selected among all the patients with pleural, ascites and pericardial effusion who had been treated in the hospital from May 2009 to May 2013. The cellblock paraffin-imbedded sections and the cell centrifugation smear had been performed to make cytological examinations of pleural, ascites and pericardial effusion for these patients. The accuracy rates of two methods and combined use of two methods in diagnosis of malignant serous cavity effusion were analyzed respectively. Results Among 560 cases, 210 were identified with malignant serous cavity effusion through the surgical pathology, fiberoptic bronchoscopy, laparoscope, imaging-guided needle biopsy and diagnostic treatment. The sensibility and specificity of the cell centrifugation smear were 57.6% and 98.8% in comparison with the cellblock paraffin-imbedded sections’ 69.5% and 99.4% respectively. There were statistically significant differences (P<0.05) between two methods. The sensibility and specificity of the combined use of the two methods were 72.3% and 100%. Conclusion Cellblock paraffin-imbedded sections demonstrated its superiority over the cell centrifugation smear in cytological examinations of serous cavity effusion. Combined use of two methods can further improve the accuracy rate in diagnosis of serous cavity effusion.
李庆国. 细胞块石蜡切片检查对恶性浆膜腔积液的诊断价值[J]. 中国医疗设备, 2015, 30(3): 111-113.
浆膜腔积液是临床多种疾病的常见并发症，脱落细胞学检查为鉴别良性和恶性浆膜腔积液的重要手段。传统的离心涂片法细胞学检查的特异性高，但由于恶性浆膜腔积液中的肿瘤细胞少且分散，其敏感性较低，易造成漏诊。细胞块石蜡切片法收集的细胞数多，可明显提高对恶性浆膜腔积液的诊断符合率，但其脱水、浸蜡等过程中会有固缩和人为损害，导致有时细胞形态不如涂片法清晰，从而造成假阴性或假阳性。笔者应用细胞块石蜡切片法与常规离心涂片法对浆膜腔积液进行细胞学检查，报道如下。. Effectiveness of Cellblock Paraffin-Imbedded Sections in Diagnosis of Malignant Serous Cavity Effusion. China Medical Devices, 2015, 30(3): 111-113.
