Discussion on the Feasibility of Small Animal High-Energy Imaging Using Coincidence SPECT with a Pinhole Collimator
ZHANG Xiu-mei1, FENG Jue1, JIA Hong-li2
1. Department of Nuclear Medicine, the Second Hospital of Hebei Medical University, Shijiazhuang Hebei 050000, China; 2. Department of Nuclear Medicine, the First Hospital of Hebei Medical University, Shijiazhuang Hebei 050031, China
Abstract：Objective This study was aimed to explore the feasibility of small animal high-energy imaging using coincidence SPECT (Single-Photon Emission Computerized Tomography) with a pinhole collimator. Methods First, the point sources of 14.8MBq’s three radionuclides (99Tcm, 131I and 18F) were placed at different distances from the central axis of the pinhole collimator respectively. Images of point sources were acquired to calculate their resolutions. Then, 99Tcm and 18F-FDG images of mice were acquired respectively. The coincidence images of the mouse were acquired on the second day. Results The images of 99Tcm point source were clear without artifacts; however, there were minor penetration and scattered artifacts in 131I and 18F images. Additionally, both images had significant circular penetration artifacts in their edges. Resolutions of 99Tcm, 131I and 18F were declined with the distance increased. At the distance of 30 mm from the pinhole collimator, their FWHM (Full-Widths-at-Half-Maximum) and FWTM (Full-Widths-at-Tenth-Maximum) resolutions were 4.3, 5.2, 7.4 mm and 7.1, 10.1, 14.5 mm respectively. The FWHM resolution of 18F showed advantages over the resolution of the images acquired by SPECT. After being zoomed in 2.5 times, both the high-energy and low-energy mice images were clear with the ring artifacts outside the effective field of view. Coincidence 18F-FDG images of the mouse were not clear. Conclusion The coincidence SPECT with the low-energy pinhole collimator can be used for small animal high-energy imaging if there was no restriction on the resolution of images.
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ZHANG Xiu-mei, FENG Jue, JIA Hong-li. Discussion on the Feasibility of Small Animal High-Energy Imaging Using Coincidence SPECT with a Pinhole Collimator. China Medical Devices, 2015, 30(3): 38-41.
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